| Title |
Brain structure and function in patients with ovarian cancer treated with first-line chemotherapy: a pilot study
|
|---|---|
| Published in |
Brain Imaging and Behavior, October 2016
|
| DOI | 10.1007/s11682-016-9608-4 |
| Pubmed ID | |
| Authors |
D. D. Correa, J. C. Root, M. Kryza-Lacombe, M. Mehta, S. Karimi, M. L. Hensley, N. Relkin |
| Abstract |
Women with ovarian cancer often undergo chemotherapy involving multiple agents. However, little is known about treatment-related central neurotoxicity in this population. The goal of this cross-sectional study was to assess brain structure and function and neurocognitive abilities in patients with ovarian cancer following first-line chemotherapy. Eighteen patients with ovarian, peritoneal and fallopian tube cancer and eighteen healthy controls matched for gender, age and education participated in the study. The patients were evaluated 1-4 months following completion of first-line taxane/platinum chemotherapy. All participants underwent structural and functional magnetic resonance imaging (MRI), and completed neuropsychological tests of attention, memory and executive functions. Neuroimaging assessments included voxel-based morphometry (VBM) for measuring gray matter (GM) volume, and functional MRI (fMRI) during the N-back working memory task. The results of VBM showed that patients had significantly reduced GM volume compared to healthy controls in the right middle/superior frontal gyrus, and in the left supramarginal gyrus and left inferior parietal lobule. fMRI results indicated significantly decreased activation in patients relative to healthy controls in the left middle frontal gyrus and left inferior parietal lobule during the N-back task (1/2/3-back >0-back). There were no statistically significant differences between the two groups on the neuropsychological tests. This is the first study showing structural and functional alterations involving frontal and parietal regions in patients with ovarian cancer treated with first-line chemotherapy. These findings are congruent with studies involving women with breast cancer, and provide additional supporting evidence for central neurotoxicity associated with taxane/platinum chemotherapy. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 76 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 14% |
| Researcher | 10 | 13% |
| Student > Master | 8 | 11% |
| Student > Bachelor | 7 | 9% |
| Other | 5 | 7% |
| Other | 12 | 16% |
| Unknown | 23 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 11 | 14% |
| Neuroscience | 11 | 14% |
| Medicine and Dentistry | 9 | 12% |
| Nursing and Health Professions | 5 | 7% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Other | 9 | 12% |
| Unknown | 28 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2018.
All research outputs
#3,080,003
of 22,896,955 outputs
Outputs from Brain Imaging and Behavior
#162
of 1,155 outputs
Outputs of similar age
#54,727
of 315,898 outputs
Outputs of similar age from Brain Imaging and Behavior
#10
of 57 outputs
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We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.