| Title |
Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease
|
|---|---|
| Published in |
Immunologic Research, May 2011
|
| DOI | 10.1007/s12026-011-8210-5 |
| Pubmed ID | |
| Authors |
Sreemanti Basu, Bonnie N. Dittel |
| Abstract |
It has become clear that the endocannabinoid system is a potent regulator of immune responses, with the cannabinoid receptor 2 (CB2) as the key component due to its high expression by all immune subtypes. CB2 has been shown to regulate immunity by a number of mechanisms including development, migration, proliferation, and effector functions. In addition, CB2 has been shown to modulate the function of all immune cell types examined to date. CB2 is a G(i)-protein-coupled receptor and thus exhibits a complex pharmacology allowing both stimulatory and inhibitory signaling that depends on receptor expression levels, ligand concentration, and cell lineage specificities. Here, we discuss both in vitro and in vivo experimental evidence that CB2 is a potent regulator of immune responses making it a prime target for the treatment of inflammatory diseases. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 50% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 50% |
| Members of the public | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 190 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 4 | 2% |
| Iran, Islamic Republic of | 1 | <1% |
| Germany | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 183 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 33 | 17% |
| Student > Ph. D. Student | 28 | 15% |
| Student > Bachelor | 23 | 12% |
| Researcher | 19 | 10% |
| Other | 10 | 5% |
| Other | 31 | 16% |
| Unknown | 46 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 17% |
| Medicine and Dentistry | 25 | 13% |
| Biochemistry, Genetics and Molecular Biology | 24 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 18 | 9% |
| Neuroscience | 13 | 7% |
| Other | 21 | 11% |
| Unknown | 57 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2020.
All research outputs
#2,809,950
of 24,143,470 outputs
Outputs from Immunologic Research
#78
of 918 outputs
Outputs of similar age
#13,230
of 114,020 outputs
Outputs of similar age from Immunologic Research
#3
of 10 outputs
Altmetric has tracked 24,143,470 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 918 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.9. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 114,020 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.