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Molecular analysis of the human SLC13A4 sulfate transporter gene promoter

Overview of attention for article published in Biochemical & Biophysical Research Communications, February 2013
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Title
Molecular analysis of the human SLC13A4 sulfate transporter gene promoter
Published in
Biochemical & Biophysical Research Communications, February 2013
DOI 10.1016/j.bbrc.2013.02.061
Pubmed ID
Authors

J. Jefferis, J. Rakoczy, D.G. Simmons, P.A. Dawson

Abstract

The human solute linked carrier (SLC) 13A4 gene is primarily expressed in the placenta where it is proposed to mediate the transport of nutrient sulfate from mother to fetus. The molecular mechanisms involved in the regulation of SLC13A4 expression remain unknown. To investigate the regulation of SLC13A4 gene expression, we analysed the transcriptional activity of the human SLC13A4 5'-flanking region in the JEG-3 placental cell line using luciferase reporter assays. Basal transcriptional activity was identified in the region -57 to -192 nucleotides upstream of the SLC13A4 transcription initiation site. Mutational analysis of the minimal promoter region identified Nuclear factor Y (NFY), Specificity protein 1 (SP1) and Krüppel like factor 7 (KLF7) motifs which conferred positive transcriptional activity, as well as Zinc finger protein of the cerebellum 2 (ZIC2) and helix-loop-helix protein 1 (HEN1) motifs that repressed transcription. The conserved NFY, SP1, KLF7, ZIC2 and HEN1 motifs in the SLC13A4 promoter of placental species but not in non-placental species, suggests a potential role for these putative transcriptional factor binding motifs in the physiological control of SLC13A4 mRNA expression.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Lecturer 2 20%
Student > Ph. D. Student 2 20%
Student > Master 2 20%
Student > Bachelor 1 10%
Lecturer > Senior Lecturer 1 10%
Other 1 10%
Unknown 1 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 50%
Medicine and Dentistry 3 30%
Biochemistry, Genetics and Molecular Biology 1 10%
Unknown 1 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2013.
All research outputs
#22,758,309
of 25,371,288 outputs
Outputs from Biochemical & Biophysical Research Communications
#23,757
of 26,637 outputs
Outputs of similar age
#181,124
of 205,030 outputs
Outputs of similar age from Biochemical & Biophysical Research Communications
#103
of 120 outputs
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