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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Pancreatic Cancer Risk Associated with Prediagnostic Plasma Levels of Leptin and Leptin Receptor Genetic Polymorphisms
|
|---|---|
| Published in |
Cancer Research, December 2016
|
| DOI | 10.1158/0008-5472.can-16-1699 |
| Pubmed ID | |
| Authors |
Ana Babic, Ying Bao, Zhi Rong Qian, Chen Yuan, Edward L Giovannucci, Hugues Aschard, Peter Kraft, Laufey T Amundadottir, Rachael Stolzenberg-Solomon, Vicente Morales-Oyarvide, Kimmie Ng, Meir J Stampfer, Shuji Ogino, Julie E Buring, Howard D Sesso, John Michael Gaziano, Nader Rifai, Michael N Pollak, Matthew L Anderson, Barbara B Cochrane, Juhua Luo, JoAnn E Manson, Charles S Fuchs, Brian M Wolpin |
| Abstract |
Leptin is an adipokine involved in regulating energy balance which has been identified as a potential biological link in development of obesity-associated cancers such as pancreatic cancer. In this prospective, nested case-control study of 470 cases and 1094 controls from five U.S. cohorts, we used conditional logistic regression to evaluate pancreatic cancer risk by prediagnostic plasma leptin, adjusting for race/ethnicity, diabetes, body-mass index, physical activity, plasma C-peptide, adiponectin, and 25-hydroxyvitamin D. Due to known differences in leptin levels by gender, analyses were conducted separately for men and women. We also evaluated associations between 32 tagging single nucleotide polymorphisms (SNPs) in the leptin receptor (LEPR) gene and pancreatic cancer risk. Leptin levels were higher in female versus male control participants (median, 20.8 vs. 6.7µg/mL; P0.0001). Among men, plasma leptin was positively associated with pancreatic cancer risk, and those in the top quintile had a multivariable-adjusted odds ratio (OR) of 3.02 compared to men in the bottom quintile (95% CI, 1.27-7.16; Ptrend=0.02). Among women, circulating leptin was not associated with pancreatic cancer risk (Ptrend=0.21). Results were similar across cohorts (Pheterogeneity=0.88 for two male cohorts and 0.35 for three female cohorts). In genetic analyses, rs10493380 in LEPR was associated with increased pancreatic cancer risk among women, with an OR per minor allele of 1.54 (95% CI, 1.18-2.02; multiple hypothesis-corrected P=0.03). No SNPs were significantly associated with risk in men. In conclusion, higher prediagnostic levels of plasma leptin were associated with an elevated risk of pancreatic cancer among men, but not among women. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| China | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 46 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 13% |
| Student > Bachelor | 6 | 13% |
| Researcher | 6 | 13% |
| Student > Master | 4 | 9% |
| Student > Postgraduate | 3 | 7% |
| Other | 8 | 17% |
| Unknown | 13 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 26% |
| Medicine and Dentistry | 12 | 26% |
| Psychology | 2 | 4% |
| Environmental Science | 1 | 2% |
| Agricultural and Biological Sciences | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 15 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2016.
All research outputs
#1,349,771
of 25,559,053 outputs
Outputs from Cancer Research
#871
of 18,675 outputs
Outputs of similar age
#26,804
of 422,239 outputs
Outputs of similar age from Cancer Research
#32
of 185 outputs
Altmetric has tracked 25,559,053 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 18,675 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 422,239 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 185 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.