| Title |
Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample
|
|---|---|
| Published in |
European Child & Adolescent Psychiatry, October 2016
|
| DOI | 10.1007/s00787-016-0914-6 |
| Pubmed ID | |
| Authors |
Rodrigo B. Mansur, Graccielle R. Cunha, Elson Asevedo, André Zugman, Adiel C. Rios, Giovanni A. Salum, Pedro M. Pan, Ary Gadelha, Mateus L. Levandowski, Síntia I. Belangero, Gisele G. Manfro, Laura Stertz, Márcia Kauer-Sant’anna, Eurípedes C. Miguel, Rodrigo A. Bressan, Jair J. Mari, Rodrigo Grassi-Oliveira, Elisa Brietzke |
| Abstract |
Replicated evidence indicates that perinatal complications are associated with increased markers of oxidative stress and with mental health problems in children. However, there are fewer reports on the impact of perinatal complications in later phases of development. We aimed to investigate the estimated effects of perinatal complications on levels of lipid peroxidation and on psychopathology in children and adolescents. The study is part of the High Risk Cohort Study for Psychiatric Disorders; the population was composed by 554 students, 6-14 years of age. Serum levels of malondialdehyde, a product of lipid peroxidation, were measured by the TBARS method. A household interview with parents and caregivers was conducted and included inquiries about perinatal history, the Child Behavior Checklist (CBCL), and parent's evaluation, using the Mini International Psychiatric Interview (MINI). We created a cumulative risk index, conceptualized as each individual's cumulative exposure to perinatal complications. Results indicate that perinatal complications were associated with higher levels of TBARS. After adjusting for age, gender, socio-economic status, CBCL total problems score, parental psychopathology, and childhood maltreatment, children exposed to 3 or more perinatal complications had an 26.9% (95% CI 9.9%, 46.6%) increase in TBARS levels, relative to the unexposed group. Exploratory mediation analysis indicated that TBARS levels partially mediated the association between perinatal complications and externalizing problems. In conclusion, an adverse intrauterine and/or early life environment, as proxied by the cumulative exposure to perinatal complications, was independently associated with higher levels of lipid peroxidation in children and adolescents. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 118 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 11% |
| Researcher | 12 | 10% |
| Student > Master | 11 | 9% |
| Student > Doctoral Student | 9 | 8% |
| Student > Ph. D. Student | 8 | 7% |
| Other | 22 | 19% |
| Unknown | 43 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 19% |
| Psychology | 16 | 14% |
| Nursing and Health Professions | 13 | 11% |
| Social Sciences | 5 | 4% |
| Agricultural and Biological Sciences | 4 | 3% |
| Other | 10 | 8% |
| Unknown | 47 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2016.
All research outputs
#20,349,664
of 22,896,955 outputs
Outputs from European Child & Adolescent Psychiatry
#1,488
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Outputs of similar age
#271,450
of 314,045 outputs
Outputs of similar age from European Child & Adolescent Psychiatry
#17
of 22 outputs
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