| Title |
The role of left ventricular deformation in the assessment of microvascular obstruction and intramyocardial haemorrhage
|
|---|---|
| Published in |
The International Journal of Cardiovascular Imaging, October 2016
|
| DOI | 10.1007/s10554-016-1006-x |
| Pubmed ID | |
| Authors |
Pankaj Garg, Ananth Kidambi, Peter P. Swoboda, James R. J. Foley, Tarique A. Musa, David P. Ripley, Bara Erhayiem, Laura E. Dobson, Adam K. McDiarmid, Graham J. Fent, Philip Haaf, John P. Greenwood, Sven Plein |
| Abstract |
In the setting of acute ST-elevation myocardial infarction (STEMI), it remains unclear which strain parameter most strongly correlates with microvascular obstruction (MVO) or intramyocardial haemorrhage (IMH). We aimed to investigate the association of MVO, IMH and convalescent left ventricular (LV) remodelling with strain parameters measured with cardiovascular magnetic resonance (CMR). Forty-three patients with reperfused STEMI and 10 age and gender matched healthy controls underwent CMR within 3-days and at 3-months following reperfused STEMI. Cine, T2-weighted, T2*-imaging and late gadolinium enhancement (LGE) imaging were performed. Infarct size, MVO and IMH were quantified. Peak global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS) and their strain rates were derived by feature tracking analysis of LV short-axis, 4-chamber and 2-chamber cines. All 43 patients and ten controls completed the baseline scan and 34 patients completed 3-month scans. In multivariate regression, GLS demonstrated the strongest association with MVO or IMH (beta = 0.53, p < 0.001). The optimal cut-off value for GLS was -13.7% for the detection of MVO or IMH (sensitivity 76% and specificity 77.8%). At follow up, 17% (n = 6) of patients had adverse LV remodeling (defined as an absolute increase of LV end-diastolic/end-systolic volumes >20%). Baseline GLS also demonstrated the strongest diagnostic performance in predicting adverse LV remodelling (AUC = 0.79; 95% CI 0.60-0.98; p = 0.03). Post-reperfused STEMI, baseline GLS was most closely associated with the presence of MVO or IMH. Baseline GLS was more strongly associated with adverse LV remodelling than other CMR parameters. |
X Demographics
The data shown below were collected from the profiles of 54 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 4% |
| United States | 1 | 2% |
| Curaçao | 1 | 2% |
| Unknown | 50 | 93% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 54 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 17% |
| Student > Doctoral Student | 6 | 14% |
| Student > Ph. D. Student | 4 | 10% |
| Other | 3 | 7% |
| Student > Master | 3 | 7% |
| Other | 9 | 21% |
| Unknown | 10 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 45% |
| Computer Science | 3 | 7% |
| Nursing and Health Professions | 2 | 5% |
| Unspecified | 1 | 2% |
| Physics and Astronomy | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 15 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 47. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2017.
All research outputs
#907,625
of 25,753,031 outputs
Outputs from The International Journal of Cardiovascular Imaging
#5
of 2,024 outputs
Outputs of similar age
#16,961
of 322,110 outputs
Outputs of similar age from The International Journal of Cardiovascular Imaging
#1
of 36 outputs
Altmetric has tracked 25,753,031 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,024 research outputs from this source. They receive a mean Attention Score of 2.3. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.