| Title |
Mechanisms underlying the anti-wasting effect of l-carnitine supplementation under pathologic conditions: evidence from experimental and clinical studies
|
|---|---|
| Published in |
European Journal of Nutrition, March 2013
|
| DOI | 10.1007/s00394-013-0511-0 |
| Pubmed ID | |
| Authors |
Robert Ringseis, Janine Keller, Klaus Eder |
| Abstract |
Loss of skeletal muscle mass, also known as muscle wasting or muscle atrophy, is a common symptom of several chronic diseases, such as cancer and infectious diseases. Due to the strong negative impact of muscle loss on patient's prognosis and quality of life, the development of efficacious treatment approaches to combat muscle wasting are of great importance. In order to evaluate the suitability of L-carnitine (LC) as an anti-wasting agent for clinical purposes the present review comprehensively summarizes the results from animal and clinical studies showing the effects of supplementation with LC or LC derivatives (acetyl-LC, propionyl-LC) on critical mechanisms involved in skeletal muscle loss under pathologic conditions, such as increased proteolysis, impaired protein synthesis, myonuclear apoptosis, inflammation, oxidative stress, and mitochondrial dysfunction. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 36% |
| Canada | 2 | 18% |
| United States | 1 | 9% |
| Dominican Republic | 1 | 9% |
| Unknown | 3 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 55% |
| Scientists | 4 | 36% |
| Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 1% |
| Unknown | 83 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 13% |
| Student > Master | 11 | 13% |
| Student > Bachelor | 11 | 13% |
| Researcher | 9 | 11% |
| Student > Postgraduate | 5 | 6% |
| Other | 15 | 18% |
| Unknown | 22 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 19% |
| Biochemistry, Genetics and Molecular Biology | 8 | 10% |
| Nursing and Health Professions | 7 | 8% |
| Sports and Recreations | 7 | 8% |
| Agricultural and Biological Sciences | 4 | 5% |
| Other | 13 | 15% |
| Unknown | 29 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 79. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2023.
All research outputs
#548,821
of 25,663,438 outputs
Outputs from European Journal of Nutrition
#150
of 2,707 outputs
Outputs of similar age
#3,600
of 210,866 outputs
Outputs of similar age from European Journal of Nutrition
#3
of 22 outputs
Altmetric has tracked 25,663,438 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,707 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.6. This one has done particularly well, scoring higher than 94% of its peers.
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We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.