| Title |
Body size regulation and insulin-like growth factor signaling
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, March 2013
|
| DOI | 10.1007/s00018-013-1313-5 |
| Pubmed ID | |
| Authors |
Seogang Hyun |
| Abstract |
How animals achieve their specific body size is a fundamental, but still largely unresolved, biological question. Over the past decades, studies on the insect model system have provided some important insights into the process of body size determination and highlighted the importance of insulin/insulin-like growth factor signaling. Fat body, the Drosophila counterpart of liver and adipose tissue, senses nutrient availability and controls larval growth rate by modulating peripheral insulin signaling. Similarly, insulin-like growth factor I produced from liver and muscle promotes postnatal body growth in mammals. Organismal growth is tightly coupled with the process of sexual maturation wherein the sex steroid hormone attenuates body growth. This review summarizes some important findings from Drosophila and mammalian studies that shed light on the general mechanism of animal size determination. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| Brazil | 1 | <1% |
| Canada | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 103 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 19% |
| Researcher | 17 | 16% |
| Student > Master | 12 | 11% |
| Student > Bachelor | 8 | 7% |
| Professor > Associate Professor | 8 | 7% |
| Other | 19 | 18% |
| Unknown | 24 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 45 | 42% |
| Biochemistry, Genetics and Molecular Biology | 16 | 15% |
| Medicine and Dentistry | 5 | 5% |
| Neuroscience | 4 | 4% |
| Environmental Science | 3 | 3% |
| Other | 10 | 9% |
| Unknown | 25 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2013.
All research outputs
#19,201,293
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#3,458
of 4,151 outputs
Outputs of similar age
#152,153
of 199,301 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#23
of 41 outputs
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