Title |
Interleukin 32: a novel player in the control of infectious diseases
|
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Published in |
Journal of Leukocyte Biology, October 2016
|
DOI | 10.1189/jlb.4ru0416-175rr |
Pubmed ID | |
Authors |
Fátima Ribeiro‐Dias, Rodrigo Saar Gomes, Lucas Luiz de Lima Silva, Jéssica Cristina dos Santos, Leo A. B. Joosten |
Abstract |
Interleukin 32 (IL-32) is a proinflammatory cytokine, expressed as 9 distinct isoforms. The most active isoform is the predominantly intracellular-functioning IL-32γ. Involvement of IL-32 in infectious diseases is increasingly being appreciated. Production of IL-32 promotes pathways that serve to control bacterial infection, especially those caused by mycobacteria. A similar role for this cytokine is observed in the cellular response to viral infections. In addition to its protective effects against microorganisms, IL-32 is involved in immunopathogenesis of some infectious diseases. In parasitic diseases, it has been demonstrated that this cytokine is induced by Leishmania infection. In this review, we summarize the present data on the role of IL-32 in infectious diseases, highlighting this cytokine as new target for control of infections. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 65 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 14 | 22% |
Researcher | 13 | 20% |
Student > Ph. D. Student | 7 | 11% |
Student > Bachelor | 6 | 9% |
Other | 3 | 5% |
Other | 6 | 9% |
Unknown | 16 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 15 | 23% |
Immunology and Microbiology | 13 | 20% |
Medicine and Dentistry | 8 | 12% |
Agricultural and Biological Sciences | 5 | 8% |
Nursing and Health Professions | 2 | 3% |
Other | 5 | 8% |
Unknown | 17 | 26% |