| Title |
The effects of intravitreal triamcinolone acetonide on experimental pre-retinal neovascularization
|
|---|---|
| Published in |
Graefe's Archive for Clinical and Experimental Ophthalmology, January 1993
|
| DOI | 10.1007/bf01681698 |
| Pubmed ID | |
| Authors |
Andrew N. Antoszyk, Justin L. Gottlieb, Robert Machemer, Diane L. Hatchell |
| Abstract |
Corticosteroids, alone or in combination with other drugs, have been shown to inhibit angiogenesis. The purpose of this study was to evaluate the efficacy of triamcinolone acetonide in a new model of preretinal neovascularization. Rabbit eyes were treated with intravitreal triamcinolone acetonide 24 h before partial liquefaction of the posterior vitreous with hyaluronidase and injection of 250,000 homologous tissue-cultured dermal fibroblasts. Triamcinolone acetonide effectively inhibited new vessel growth in treated eyes. Only 14% of the treated eyes developed new blood vessels compared to 100% of sham-injected control eyes (P < 0.001). These results suggest that intravitreal triamcinolone acetonide might be effective in inhibiting new vessel growth in patients with inflammatory retinal neovascularization, such as that associated with sarcoidosis or other uveitic syndromes. |
Mendeley readers
The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 3 | 23% |
| Student > Bachelor | 2 | 15% |
| Professor | 2 | 15% |
| Student > Master | 2 | 15% |
| Researcher | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 3 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 69% |
| Biochemistry, Genetics and Molecular Biology | 1 | 8% |
| Unknown | 3 | 23% |