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SLC13 family of Na+-coupled di- and tri-carboxylate/sulfate transporters

Overview of attention for article published in Molecular Aspects of Medicine, April 2013
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Title
SLC13 family of Na+-coupled di- and tri-carboxylate/sulfate transporters
Published in
Molecular Aspects of Medicine, April 2013
DOI 10.1016/j.mam.2012.12.001
Pubmed ID
Authors

M.J. Bergeron, B. Clémençon, M.A. Hediger, D. Markovich

Abstract

The SLC13 family comprises five genes (SLC13A1, SLC13A2, SLC13A3, SLC13A4, and SLC13A5) encoding structurally related multi-spanning transporters (8-13 transmembrane domains) with orthologues found in prokaryotes and eukaryotes. Mammalian SLC13 members mediate the electrogenic Na(+)-coupled anion cotransport at the plasma membrane of epithelial cells (mainly kidney, small intestine, placenta and liver) or cells of the central nervous system. While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and α-ketoglutarate. All these transporters play a variety of physiological and pathophysiological roles in the different organs. Thus, the purpose of this review is to summarize the roles of SLC13 members in human physiology and pathophysiology and what the therapeutic perspectives are. We have also described the most recent advances on the structure, expression, function and regulation of SLC13 transporters.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 <1%
Unknown 108 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 16%
Researcher 17 16%
Student > Bachelor 12 11%
Professor > Associate Professor 9 8%
Professor 8 7%
Other 24 22%
Unknown 22 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 24%
Biochemistry, Genetics and Molecular Biology 19 17%
Medicine and Dentistry 14 13%
Chemistry 7 6%
Nursing and Health Professions 3 3%
Other 12 11%
Unknown 28 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2013.
All research outputs
#22,760,732
of 25,374,917 outputs
Outputs from Molecular Aspects of Medicine
#584
of 645 outputs
Outputs of similar age
#186,923
of 212,991 outputs
Outputs of similar age from Molecular Aspects of Medicine
#27
of 28 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.