Title |
Axial and limb muscle development: dialogue with the neighbourhood
|
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Published in |
Cellular and Molecular Life Sciences, June 2016
|
DOI | 10.1007/s00018-016-2298-7 |
Pubmed ID | |
Authors |
Marianne Deries, Sólveig Thorsteinsdóttir |
Abstract |
Skeletal muscles are part of the musculoskeletal system which also includes nerves, tendons, connective tissue, bones and blood vessels. Here we review the development of axial and limb muscles in amniotes within the context of their surrounding tissues in vivo. We highlight the reciprocal dialogue mediated by signalling factors between cells of these adjacent tissues and developing muscles and also demonstrate its importance from the onset of muscle cell differentiation well into foetal development. Early embryonic tissues secrete factors which are important regulators of myogenesis. However, later muscle development relies on other tissue collaborators, such as developing nerves and connective tissue, which are in turn influenced by the developing muscles themselves. We conclude that skeletal muscle development in vivo is a compelling example of the importance of reciprocal interactions between developing tissues for the complete and coordinated development of a functional system. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Portugal | 2 | 3% |
Spain | 1 | 1% |
Unknown | 76 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 22% |
Student > Master | 12 | 15% |
Student > Bachelor | 10 | 13% |
Researcher | 9 | 11% |
Student > Doctoral Student | 8 | 10% |
Other | 14 | 18% |
Unknown | 9 | 11% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 31 | 39% |
Agricultural and Biological Sciences | 17 | 22% |
Medicine and Dentistry | 6 | 8% |
Engineering | 4 | 5% |
Neuroscience | 2 | 3% |
Other | 5 | 6% |
Unknown | 14 | 18% |