| Title |
The Role of Arginine–Nitric Oxide Pathway in Patients with Alzheimer Disease
|
|---|---|
| Published in |
Biological Trace Element Research, December 2008
|
| DOI | 10.1007/s12011-008-8291-8 |
| Pubmed ID | |
| Authors |
Huseyin Vural, Burcu Sirin, Nigar Yilmaz, Ibrahim Eren, Namik Delibas |
| Abstract |
There is a reciprocal regulation of arginase and nitric oxide synthase in L-arginine-metabolizing pathways. There are various evidences of the role of nitric oxide in several neuropsychiatric disorders including Alzheimer's disease. However, there is no study that has investigated the role of arginase as an important part of the arginine regulatory system affecting nitric oxide synthase activity in Alzheimer's disease. This study aims to investigate arginase, manganese (a cofactor of arginase), and total nitrite levels (a metabolite of NO) and their relationship to the arginine-NO pathway in patients with Alzheimer's disease. Arginase activities, Mn, and total nitrite levels were measured in plasma from 47 patients with Alzheimer's disease and 43 healthy control subjects. Plasma arginase activities and manganese were found to be significantly lower and total nitrite level higher in patients with Alzheimer's disease compared with controls. Our results suggest that the arginine-NO pathway is involved in the pathogenesis of Alzheimer's disease. |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 5% |
| United States | 1 | 3% |
| Unknown | 35 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 21% |
| Student > Bachelor | 6 | 16% |
| Student > Ph. D. Student | 5 | 13% |
| Other | 4 | 11% |
| Professor | 3 | 8% |
| Other | 6 | 16% |
| Unknown | 6 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 18% |
| Medicine and Dentistry | 5 | 13% |
| Biochemistry, Genetics and Molecular Biology | 5 | 13% |
| Computer Science | 3 | 8% |
| Neuroscience | 3 | 8% |
| Other | 7 | 18% |
| Unknown | 8 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2013.
All research outputs
#20,185,720
of 22,701,287 outputs
Outputs from Biological Trace Element Research
#1,565
of 2,013 outputs
Outputs of similar age
#161,918
of 167,640 outputs
Outputs of similar age from Biological Trace Element Research
#8
of 8 outputs
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