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Detection of sharing by descent, long-range phasing and haplotype imputation

Overview of attention for article published in Nature Genetics, August 2008
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Citations

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407 Dimensions

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476 Mendeley
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6 CiteULike
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4 Connotea
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Title
Detection of sharing by descent, long-range phasing and haplotype imputation
Published in
Nature Genetics, August 2008
DOI 10.1038/ng.216
Pubmed ID
Authors

Augustine Kong, Gisli Masson, Michael L Frigge, Arnaldur Gylfason, Pasha Zusmanovich, Gudmar Thorleifsson, Pall I Olason, Andres Ingason, Stacy Steinberg, Thorunn Rafnar, Patrick Sulem, Magali Mouy, Frosti Jonsson, Unnur Thorsteinsdottir, Daniel F Gudbjartsson, Hreinn Stefansson, Kari Stefansson

Abstract

Uncertainty about the phase of strings of SNPs creates complications in genetic analysis, although methods have been developed for phasing population-based samples. However, these methods can only phase a small number of SNPs effectively and become unreliable when applied to SNPs spanning many linkage disequilibrium (LD) blocks. Here we show how to phase more than 1,000 SNPs simultaneously for a large fraction of the 35,528 Icelanders genotyped by Illumina chips. Moreover, haplotypes that are identical by descent (IBD) between close and distant relatives, for example, those separated by ten meioses or more, can often be reliably detected. This method is particularly powerful in studies of the inheritance of recurrent mutations and fine-scale recombinations in large sample sets. A further extension of the method allows us to impute long haplotypes for individuals who are not genotyped.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 476 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 13 3%
United Kingdom 8 2%
Germany 3 <1%
Brazil 3 <1%
France 2 <1%
Italy 2 <1%
Australia 2 <1%
Denmark 2 <1%
Canada 2 <1%
Other 10 2%
Unknown 429 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 141 30%
Student > Ph. D. Student 120 25%
Student > Bachelor 29 6%
Student > Master 27 6%
Professor 27 6%
Other 78 16%
Unknown 54 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 225 47%
Biochemistry, Genetics and Molecular Biology 75 16%
Medicine and Dentistry 45 9%
Mathematics 19 4%
Computer Science 18 4%
Other 28 6%
Unknown 66 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 51. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2023.
All research outputs
#737,951
of 23,664,651 outputs
Outputs from Nature Genetics
#1,391
of 7,298 outputs
Outputs of similar age
#1,448
of 84,203 outputs
Outputs of similar age from Nature Genetics
#4
of 58 outputs
Altmetric has tracked 23,664,651 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,298 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.8. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 84,203 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.