| Title |
Frailty in relation to the risk of Alzheimer's disease, dementia, and death in older Chinese adults: A seven-year prospective study
|
|---|---|
| Published in |
The journal of nutrition, health & aging, June 2017
|
| DOI | 10.1007/s12603-016-0798-7 |
| Pubmed ID | |
| Authors |
C. Wang, X. Ji, X. Wu, Z. Tang, X. Zhang, S. Guan, H. Liu, Xianghua Fang |
| Abstract |
To explore the relationship of general health decline assessed by frailty and risk of dementia and Alzheimer's disease (AD). A seven-year prospective cohort study. Secondary analysis of data from the Beijing Longitudinal Study on Aging. Urban and rural community-dwelling people aged 60 and older at baseline. Frailty was quantified using the deficit accumulation-based frailty index (FI), constructed from 40 health deficits at baseline. Dementia was diagnosed by DSM-IIIR. AD and vascular dementia (VaD) were diagnosed by NINCDS-ADRDA and NINDS-AIREN. The relationships between frailty and the risk of dementia, AD and death were evaluated through multivariable models. Of 2788 participants at baseline (1997), 171 (11.1%) reported a history of dementia. In seven years, 351 people developed dementia (13%: 223 AD and 128 other types of dementia) and 813 died (29%). After adjustment for age, sex, education, and baseline cognition, baseline frailty status significantly associated with Alzheimer's disease and dementia and death. For each deficit accumulated, the odds ratio of death increased by 5.7%, and the odds ratio of dementia increased by 2.9% (p < 0.001). Frailty was associated with Alzheimer's disease and dementia over a seven years period. Frailty index might facilitate the identification of older adults at high risk of dementia for the application of the most effective, targeted prevention strategies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 75 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 13% |
| Researcher | 9 | 12% |
| Other | 7 | 9% |
| Student > Bachelor | 7 | 9% |
| Student > Postgraduate | 7 | 9% |
| Other | 18 | 24% |
| Unknown | 17 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 24% |
| Nursing and Health Professions | 11 | 15% |
| Neuroscience | 6 | 8% |
| Social Sciences | 5 | 7% |
| Psychology | 4 | 5% |
| Other | 12 | 16% |
| Unknown | 19 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2018.
All research outputs
#2,142,990
of 25,540,105 outputs
Outputs from The journal of nutrition, health & aging
#261
of 1,985 outputs
Outputs of similar age
#39,777
of 330,904 outputs
Outputs of similar age from The journal of nutrition, health & aging
#3
of 31 outputs
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