↓ Skip to main content

Circular transcripts of the testis-determining gene Sry in adult mouse testis

Overview of attention for article published in Cell, June 1993
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

twitter
11 X users
patent
6 patents
wikipedia
1 Wikipedia page

Citations

dimensions_citation
956 Dimensions

Readers on

mendeley
449 Mendeley
citeulike
2 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Circular transcripts of the testis-determining gene Sry in adult mouse testis
Published in
Cell, June 1993
DOI 10.1016/0092-8674(93)90279-y
Pubmed ID
Authors

Blanche Capel, Amanda Swain, Silvia Nicolis, Adam Hacker, Michael Walter, Peter Koopman, Peter Goodfellow, Robin Lovell-Badge

Abstract

Sry is expressed at higher levels in the adult testis, where no function has been determined, than in the genital ridge, its critical site of action. cDNA and 5' RACE clones isolated from testis or from Sry-transfected cell lines have an unusual structure, with 3' sequences located in a 5' position. RNAase protection assays and reverse transcription polymerase chain reactions confirmed that these unusual RNA molecules represent the most abundant transcript in testis. Furthermore, oligonucleotide hybridization and RNAase H digestion proved that these Sry RNA molecules are circular. Similar transcripts were detected in the testes of mice with Mus musculus musculus, Mus musculus domesticus, and Mus spretus Sry genes. The circular RNA is found in the cytoplasm but is not substantially bound to polysomes. We suggest that the circles arise from normal splicing processes as a consequence of the unusual genomic structure surrounding the Sry locus in the mouse.

X Demographics

X Demographics

The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 449 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 <1%
Denmark 2 <1%
Japan 2 <1%
Chile 1 <1%
Canada 1 <1%
France 1 <1%
Netherlands 1 <1%
Czechia 1 <1%
Unknown 436 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 94 21%
Researcher 72 16%
Student > Bachelor 63 14%
Student > Master 54 12%
Student > Doctoral Student 21 5%
Other 53 12%
Unknown 92 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 151 34%
Agricultural and Biological Sciences 134 30%
Medicine and Dentistry 24 5%
Neuroscience 12 3%
Chemistry 9 2%
Other 23 5%
Unknown 96 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2023.
All research outputs
#2,039,035
of 25,371,288 outputs
Outputs from Cell
#5,592
of 17,169 outputs
Outputs of similar age
#450
of 19,289 outputs
Outputs of similar age from Cell
#6
of 100 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,169 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.1. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 19,289 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 100 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.