Title |
Hippocampal volume and cell density changes in a mouse model of human genetic epilepsy
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Published in |
Neurology, March 2013
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DOI | 10.1212/wnl.0b013e31828970ec |
Pubmed ID | |
Authors |
Kay L. Richards, Nyoman D. Kurniawan, Zhengyi Yang, Tae Hwan Kim, Marianne D. Keller, Jun Low, Jeremy F.P. Ullmann, Stacey Cole, Samuel Foong, Graham J. Galloway, Christopher A. Reid, George Paxinos, David C. Reutens, Steven Petrou |
Abstract |
The human γ-aminobutyric acid type A (GABAA)γ2R43Q (R43Q) mutation is associated with genetic epilepsy with febrile seizures. R43Q mice in the C57Bl/6J background do not display spontaneous seizures, but are significantly more susceptible to hyperthermic seizures, providing a model with enhanced seizure susceptibility without the confounding influence of ongoing epileptic activity. Because of GABA's role in brain development, we sought to determine whether the R43Q mutation alters brain structure before the appearance of seizures. |
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