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Hippocampal volume and cell density changes in a mouse model of human genetic epilepsy

Overview of attention for article published in Neurology, March 2013
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Title
Hippocampal volume and cell density changes in a mouse model of human genetic epilepsy
Published in
Neurology, March 2013
DOI 10.1212/wnl.0b013e31828970ec
Pubmed ID
Authors

Kay L. Richards, Nyoman D. Kurniawan, Zhengyi Yang, Tae Hwan Kim, Marianne D. Keller, Jun Low, Jeremy F.P. Ullmann, Stacey Cole, Samuel Foong, Graham J. Galloway, Christopher A. Reid, George Paxinos, David C. Reutens, Steven Petrou

Abstract

The human γ-aminobutyric acid type A (GABAA)γ2R43Q (R43Q) mutation is associated with genetic epilepsy with febrile seizures. R43Q mice in the C57Bl/6J background do not display spontaneous seizures, but are significantly more susceptible to hyperthermic seizures, providing a model with enhanced seizure susceptibility without the confounding influence of ongoing epileptic activity. Because of GABA's role in brain development, we sought to determine whether the R43Q mutation alters brain structure before the appearance of seizures.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
United States 1 2%
France 1 2%
Unknown 39 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 24%
Student > Ph. D. Student 9 21%
Student > Doctoral Student 3 7%
Student > Postgraduate 3 7%
Student > Master 3 7%
Other 7 17%
Unknown 7 17%
Readers by discipline Count As %
Medicine and Dentistry 15 36%
Agricultural and Biological Sciences 6 14%
Engineering 4 10%
Psychology 2 5%
Biochemistry, Genetics and Molecular Biology 2 5%
Other 3 7%
Unknown 10 24%