Title |
Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes
|
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Published in |
Genome Biology, March 2013
|
DOI | 10.1186/gb-2013-14-3-r25 |
Pubmed ID | |
Authors |
James P Reddington, Sara M Perricone, Colm E Nestor, Judith Reichmann, Neil A Youngson, Masako Suzuki, Diana Reinhardt, Donncha S Dunican, James G Prendergast, Heidi Mjoseng, Bernard H Ramsahoye, Emma Whitelaw, John M Greally, Ian R Adams, Wendy A Bickmore, Richard R Meehan |
Abstract |
DNA methylation and the Polycomb repression system are epigenetic mechanisms that play important roles in maintaining transcriptional repression. Recent evidence suggests that DNA methylation can attenuate the binding of Polycomb protein components to chromatin and thus plays a role in determining their genomic targeting. However, whether this role of DNA methylation is important in the context of transcriptional regulation is unclear. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 2% |
United Kingdom | 3 | 1% |
Netherlands | 1 | <1% |
Sweden | 1 | <1% |
Germany | 1 | <1% |
Canada | 1 | <1% |
Portugal | 1 | <1% |
Japan | 1 | <1% |
Russia | 1 | <1% |
Other | 0 | 0% |
Unknown | 282 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 97 | 33% |
Researcher | 59 | 20% |
Student > Master | 28 | 9% |
Student > Bachelor | 20 | 7% |
Professor | 14 | 5% |
Other | 43 | 14% |
Unknown | 36 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 117 | 39% |
Biochemistry, Genetics and Molecular Biology | 105 | 35% |
Medicine and Dentistry | 13 | 4% |
Neuroscience | 5 | 2% |
Computer Science | 3 | 1% |
Other | 15 | 5% |
Unknown | 39 | 13% |