Title |
Effects on retention of posttraining amphetamine injections in mice: Interaction with pretraining experience
|
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Published in |
Psychopharmacology, January 1977
|
DOI | 10.1007/bf00426535 |
Pubmed ID | |
Authors |
John W. Haycock, Roderick van Buskirk, Paul E. Gold |
Abstract |
These experiments examined the effects of d-amphethamine on retention of one-trial inhibitory (passive) avoidance training in mice. Water-deprived mice were pretrained to lick from a water spout at the end of a darkened compartment. Footshock was administered during licking after 4, 6, or 7 days of pretraining. Retention performance (latency to lick) was measured 24 h after training. The effects on memory of posttraining amphetamine varied not only with amphetamine dose but also with the amount of pretraining. In animals pretraining for 7 days, 0.3 and 1.0 mg/kg but not 0.03, 0.1, or 3.0 mg/kg posttraining amphetamine significantly enhanced later retention performance. In mice pretrained for 6 days, 1 mg/kg amphetamine also enhanced retention performance. However, in mice pretrained for only 4 days, 1 mg/kg amphetamine impaired later retention erd for only 4 days, 1 mg/kg amphetamine impaired later retention performance. These results are consistent with the view that posttraining treatment may affect memory storage processes by interacting with training-related arousal levels. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 4 | 36% |
Student > Bachelor | 4 | 36% |
Professor | 2 | 18% |
Student > Ph. D. Student | 1 | 9% |
Readers by discipline | Count | As % |
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Computer Science | 1 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 9% |
Medicine and Dentistry | 1 | 9% |
Other | 1 | 9% |