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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mitochondrial hormesis links low‐dose arsenite exposure to lifespan extension
|
|---|---|
| Published in |
Aging Cell, May 2013
|
| DOI | 10.1111/acel.12076 |
| Pubmed ID | |
| Authors |
Sebastian Schmeisser, Kathrin Schmeisser, Sandra Weimer, Marco Groth, Steffen Priebe, Eugen Fazius, Doreen Kuhlow, Denis Pick, Jürgen W Einax, Reinhard Guthke, Matthias Platzer, Kim Zarse, Michael Ristow |
| Abstract |
Arsenite is one of the most toxic chemical substances known and is assumed to exert detrimental effects on viability even at lowest concentrations. By contrast and unlike higher concentrations, we here find that exposure to low-dose arsenite promotes growth of cultured mammalian cells. In the nematode C. elegans, low-dose arsenite promotes resistance against thermal and chemical stressors and extends lifespan of this metazoan, whereas higher concentrations reduce longevity. While arsenite causes a transient increase in reactive oxygen species (ROS) levels in C. elegans, co-exposure to ROS scavengers prevents the lifespan-extending capabilities of arsenite, indicating that transiently increased ROS levels act as transducers of arsenite effects on lifespan, a process known as mitohormesis. This requires two transcription factors, namely DAF-16 and SKN-1, which employ the metallothionein MTL-2 as well as the mitochondrial transporter TIN-9.1 to extend lifespan. Taken together, low-dose arsenite extends lifespan, providing evidence for nonlinear dose-response characteristics of toxin-mediated stress resistance and longevity in a multicellular organism. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 14% |
| United Kingdom | 2 | 10% |
| Germany | 2 | 10% |
| Austria | 1 | 5% |
| Spain | 1 | 5% |
| Canada | 1 | 5% |
| Unknown | 11 | 52% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 76% |
| Scientists | 3 | 14% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 3% |
| Spain | 2 | 2% |
| Brazil | 1 | <1% |
| India | 1 | <1% |
| Belgium | 1 | <1% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Unknown | 119 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 22% |
| Researcher | 25 | 19% |
| Student > Master | 18 | 14% |
| Student > Bachelor | 13 | 10% |
| Student > Postgraduate | 8 | 6% |
| Other | 24 | 18% |
| Unknown | 14 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 58 | 44% |
| Biochemistry, Genetics and Molecular Biology | 28 | 21% |
| Medicine and Dentistry | 14 | 11% |
| Environmental Science | 2 | 2% |
| Engineering | 2 | 2% |
| Other | 6 | 5% |
| Unknown | 21 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2023.
All research outputs
#1,407,715
of 23,901,621 outputs
Outputs from Aging Cell
#419
of 2,224 outputs
Outputs of similar age
#11,573
of 195,176 outputs
Outputs of similar age from Aging Cell
#9
of 43 outputs
Altmetric has tracked 23,901,621 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,224 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.7. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,176 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.