| Title |
FGF-2 Low Molecular Weight Selectively Promotes Neuritogenesis of Motor Neurons In Vitro
|
|---|---|
| Published in |
Molecular Neurobiology, December 2012
|
| DOI | 10.1007/s12035-012-8389-z |
| Pubmed ID | |
| Authors |
Ilary Allodi, Laura Casals-Díaz, Eva Santos-Nogueira, Francisco Gonzalez-Perez, Xavier Navarro, Esther Udina |
| Abstract |
In this study, we screened in vitro the different capabilities of trophic factors with promising effect for enhancing selective regeneration and thus promoting specific reinnervation of target organs after peripheral nerve regeneration. We found that FGF-2 (18 kDa) was the trophic factor that exerted the most selective effect in promoting neurite outgrowth of spinal motoneurons both in terms of elongation and arborization. The mechanism underlying this effect on neuritogenesis seems related to FGF-2 enhancing the interaction between FGFR-1 and PSA-NCAM. The interaction of these two receptors is important during the early stages of neuritogenesis and pathfinding, while integrin alpha7B subunit seems to play a role during neurite stabilization. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 6% |
| Unknown | 32 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 41% |
| Researcher | 5 | 15% |
| Student > Doctoral Student | 4 | 12% |
| Student > Master | 3 | 9% |
| Student > Postgraduate | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 3 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 26% |
| Medicine and Dentistry | 6 | 18% |
| Biochemistry, Genetics and Molecular Biology | 3 | 9% |
| Neuroscience | 3 | 9% |
| Nursing and Health Professions | 2 | 6% |
| Other | 6 | 18% |
| Unknown | 5 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2013.
All research outputs
#18,333,600
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Outputs from Molecular Neurobiology
#2,449
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Outputs of similar age
#217,874
of 280,489 outputs
Outputs of similar age from Molecular Neurobiology
#11
of 15 outputs
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