Title |
CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis
|
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Published in |
Journal of Molecular Histology, November 2016
|
DOI | 10.1007/s10735-016-9702-3 |
Pubmed ID | |
Authors |
Swati Iyer, Yash Chhabra, Tracey J. Harvey, Richard Wang, Han Sheng Chiu, A. G. Smith, Walter G. Thomas, David J. Pennisi, Michael Piper |
Abstract |
Endothelial cells form a critical component of the coronary vasculature, yet the factors regulating their development remain poorly defined. Here we reveal a novel role for the transmembrane protein CRIM1 in mediating cardiac endothelial cell development. In the absence of Crim1 in vivo, the coronary vasculature is malformed, the number of endothelial cells reduced, and the canonical BMP pathway dysregulated. Moreover, we reveal that CRIM1 can bind IGFs, and regulate IGF signalling within endothelial cells. Finally, loss of CRIM1 from human cardiac endothelial cells results in misregulation of endothelial genes, predicted by pathway analysis to be involved in an increased inflammatory response and cytolysis, reminiscent of endothelial cell dysfunction in cardiovascular disease pathogenesis. Collectively, these findings implicate CRIM1 in endothelial cell development and homeostasis in the coronary vasculature. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 2 | 20% |
Researcher | 2 | 20% |
Lecturer > Senior Lecturer | 1 | 10% |
Student > Bachelor | 1 | 10% |
Lecturer | 1 | 10% |
Other | 2 | 20% |
Unknown | 1 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 50% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 20% |
Agricultural and Biological Sciences | 1 | 10% |
Neuroscience | 1 | 10% |
Unknown | 1 | 10% |