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Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib

Overview of attention for article published in British Journal of Cancer, March 2013
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4 X users
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1 Facebook page

Citations

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113 Dimensions

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111 Mendeley
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Title
Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib
Published in
British Journal of Cancer, March 2013
DOI 10.1038/bjc.2013.120
Pubmed ID
Authors

W Y Sanchez, S L McGee, T Connor, B Mottram, A Wilkinson, J P Whitehead, S Vuckovic, L Catley

Abstract

Dichloroacetate (DCA), through the inhibition of aerobic glycolysis (the 'Warburg effect') and promotion of pyruvate oxidation, induces growth reduction in many tumours and is now undergoing several clinical trials. If aerobic glycolysis is active in multiple myeloma (MM) cells, it can be potentially targeted by DCA to induce myeloma growth inhibition.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Germany 1 <1%
Italy 1 <1%
Canada 1 <1%
Unknown 106 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 23%
Researcher 14 13%
Student > Master 14 13%
Student > Bachelor 12 11%
Student > Postgraduate 8 7%
Other 11 10%
Unknown 27 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 23 21%
Medicine and Dentistry 22 20%
Agricultural and Biological Sciences 16 14%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Immunology and Microbiology 4 4%
Other 10 9%
Unknown 31 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 December 2014.
All research outputs
#12,581,569
of 22,703,044 outputs
Outputs from British Journal of Cancer
#8,306
of 10,354 outputs
Outputs of similar age
#99,027
of 197,767 outputs
Outputs of similar age from British Journal of Cancer
#76
of 120 outputs
Altmetric has tracked 22,703,044 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,354 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,767 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 120 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.