| Title |
The peroxisome proliferator-activated receptor (PPAR) β/δ agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells
|
|---|---|
| Published in |
Diabetologia, December 2011
|
| DOI | 10.1007/s00125-011-2401-4 |
| Pubmed ID | |
| Authors |
L. Serrano-Marco, E. Barroso, I. El Kochairi, X. Palomer, L. Michalik, W. Wahli, M. Vázquez-Carrera |
| Abstract |
IL-6 induces insulin resistance by activating signal transducer and activator of transcription 3 (STAT3) and upregulating the transcription of its target gene SOCS3. Here we examined whether the peroxisome proliferator-activated receptor (PPAR)β/δ agonist GW501516 prevented activation of the IL-6-STAT3-suppressor of cytokine signalling 3 (SOCS3) pathway and insulin resistance in human hepatic HepG2 cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 3% |
| Germany | 1 | 1% |
| United Kingdom | 1 | 1% |
| Spain | 1 | 1% |
| Japan | 1 | 1% |
| Unknown | 64 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 19% |
| Student > Ph. D. Student | 9 | 13% |
| Student > Doctoral Student | 8 | 11% |
| Student > Bachelor | 8 | 11% |
| Professor | 6 | 9% |
| Other | 14 | 20% |
| Unknown | 12 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 28 | 40% |
| Medicine and Dentistry | 8 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 10% |
| Biochemistry, Genetics and Molecular Biology | 7 | 10% |
| Immunology and Microbiology | 3 | 4% |
| Other | 2 | 3% |
| Unknown | 15 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2023.
All research outputs
#18,945,879
of 23,477,147 outputs
Outputs from Diabetologia
#4,780
of 5,141 outputs
Outputs of similar age
#185,598
of 229,370 outputs
Outputs of similar age from Diabetologia
#53
of 56 outputs
Altmetric has tracked 23,477,147 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.