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Modifying muscular dystrophy through transforming growth factor‐β

Overview of attention for article published in FEBS Journal, April 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (65th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

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1 X user
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4 patents

Citations

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60 Dimensions

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61 Mendeley
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Title
Modifying muscular dystrophy through transforming growth factor‐β
Published in
FEBS Journal, April 2013
DOI 10.1111/febs.12266
Pubmed ID
Authors

Ermelinda Ceco, Elizabeth M. McNally

Abstract

Muscular dystrophy arises from ongoing muscle degeneration and insufficient regeneration. This imbalance leads to loss of muscle, with replacement by scar or fibrotic tissue, resulting in muscle weakness and, eventually, loss of muscle function. Human muscular dystrophy is characterized by a wide range of disease severity, even when the same genetic mutation is present. This variability implies that other factors, both genetic and environmental, modify the disease outcome. There has been an ongoing effort to define the genetic and molecular bases that influence muscular dystrophy onset and progression. Modifier genes for muscle disease have been identified through both candidate gene approaches and genome-wide surveys. Multiple lines of experimental evidence have now converged on the transforming growth factor-β (TGF-β) pathway as a modifier for muscular dystrophy. TGF-β signaling is upregulated in dystrophic muscle as a result of a destabilized plasma membrane and/or an altered extracellular matrix. Given the important biological role of the TGF-β pathway, and its role beyond muscle homeostasis, we review modifier genes that alter the TGF-β pathway and approaches to modulate TGF-β activity to ameliorate muscle disease.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Unknown 60 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 20%
Researcher 10 16%
Professor > Associate Professor 6 10%
Professor 5 8%
Student > Master 5 8%
Other 12 20%
Unknown 11 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 33%
Biochemistry, Genetics and Molecular Biology 13 21%
Medicine and Dentistry 6 10%
Neuroscience 3 5%
Veterinary Science and Veterinary Medicine 2 3%
Other 3 5%
Unknown 14 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2020.
All research outputs
#8,261,140
of 25,371,288 outputs
Outputs from FEBS Journal
#4,069
of 12,259 outputs
Outputs of similar age
#67,766
of 205,935 outputs
Outputs of similar age from FEBS Journal
#34
of 148 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 12,259 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 205,935 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 148 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.