| Title |
Oligodendrocytes: biology and pathology
|
|---|---|
| Published in |
Acta Neuropathologica, October 2009
|
| DOI | 10.1007/s00401-009-0601-5 |
| Pubmed ID | |
| Authors |
Monika Bradl, Hans Lassmann |
| Abstract |
Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are the end product of a cell lineage which has to undergo a complex and precisely timed program of proliferation, migration, differentiation, and myelination to finally produce the insulating sheath of axons. Due to this complex differentiation program, and due to their unique metabolism/physiology, oligodendrocytes count among the most vulnerable cells of the CNS. In this review, we first describe the different steps eventually culminating in the formation of mature oligodendrocytes and myelin sheaths, as they were revealed by studies in rodents. We will then show differences and similarities of human oligodendrocyte development. Finally, we will lay out the different pathways leading to oligodendrocyte and myelin loss in human CNS diseases, and we will reveal the different principles leading to the restoration of myelin sheaths or to a failure to do so. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 20% |
| United Kingdom | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,408 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | <1% |
| Germany | 6 | <1% |
| Spain | 4 | <1% |
| United Kingdom | 3 | <1% |
| France | 2 | <1% |
| Portugal | 2 | <1% |
| Czechia | 2 | <1% |
| Netherlands | 1 | <1% |
| Sweden | 1 | <1% |
| Other | 12 | <1% |
| Unknown | 1368 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 274 | 19% |
| Student > Bachelor | 231 | 16% |
| Student > Master | 202 | 14% |
| Researcher | 152 | 11% |
| Student > Doctoral Student | 68 | 5% |
| Other | 157 | 11% |
| Unknown | 324 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 294 | 21% |
| Neuroscience | 238 | 17% |
| Biochemistry, Genetics and Molecular Biology | 194 | 14% |
| Medicine and Dentistry | 139 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 39 | 3% |
| Other | 142 | 10% |
| Unknown | 362 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 70. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2023.
All research outputs
#597,447
of 25,071,270 outputs
Outputs from Acta Neuropathologica
#76
of 2,513 outputs
Outputs of similar age
#1,350
of 102,791 outputs
Outputs of similar age from Acta Neuropathologica
#1
of 14 outputs
Altmetric has tracked 25,071,270 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,513 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.4. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 102,791 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.