Title |
Vitamin D deficiency and anemia: a cross-sectional study
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Published in |
Annals of Hematology, October 2009
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DOI | 10.1007/s00277-009-0850-3 |
Pubmed ID | |
Authors |
John J. Sim, Peter T. Lac, In Lu A. Liu, Samuel O. Meguerditchian, Victoria A. Kumar, Dean A. Kujubu, Scott A. Rasgon |
Abstract |
Vitamin D has been suggested to have an effect on erythropoiesis. We sought to evaluate the prevalence of anemia in a population of individuals with vitamin D deficiency compared with those with normal levels in a population of a large integrated healthplan. A cross-sectional analysis in the period 1 January 2004 through 31 December 2006 of subjects with documented concurrent levels of 25-hydroxyvitamin D and hemoglobin were evaluated. Vitamin D deficiency was defined as <30 ng/mL and anemia was defined as a hemoglobin <11 g/dL. A total of 554 subjects were included in the analysis. Anemia was present in 49% of 25-hydroxyvitamin D-deficient subjects compared with 36% with normal 25-hydroxyvitamin D levels (p < 0.01). Odds ratio for anemia in subjects with 25-hydroxyvitamin D deficiency using logistic regressions and controlling for age, gender, and chronic kidney disease was 1.9 (95% CI 1.3-2.7). 25-hydroxyvitamin D-deficient subjects had a lower mean Hb (11.0 vs. 11.7; p = 0.12 ) and a higher prevalence of erythrocyte stimulating agent use (47% vs. 24%; p < 0.05). This study demonstrates an association of vitamin D deficiency and a greater risk of anemia, lower mean hemoglobin, and higher usage of erythrocyte-stimulating agents. Future randomized studies are warranted to examine whether vitamin D directly affects erythropoiesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Argentina | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 171 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 28 | 16% |
Student > Master | 19 | 11% |
Student > Ph. D. Student | 16 | 9% |
Researcher | 14 | 8% |
Other | 11 | 6% |
Other | 39 | 22% |
Unknown | 47 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 64 | 37% |
Nursing and Health Professions | 13 | 7% |
Agricultural and Biological Sciences | 11 | 6% |
Biochemistry, Genetics and Molecular Biology | 10 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
Other | 17 | 10% |
Unknown | 53 | 30% |