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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Host and Environmental Factors Influencing Individual Human Cytokine Responses
|
|---|---|
| Published in |
Cell, November 2016
|
| DOI | 10.1016/j.cell.2016.10.018 |
| Pubmed ID | |
| Authors |
Rob ter Horst, Martin Jaeger, Sanne P. Smeekens, Marije Oosting, Morris A. Swertz, Yang Li, Vinod Kumar, Dimitri A. Diavatopoulos, Anne F.M. Jansen, Heidi Lemmers, Helga Toenhake-Dijkstra, Antonius E. van Herwaarden, Matthijs Janssen, Renate G. van der Molen, Irma Joosten, Fred C.G.J. Sweep, Johannes W. Smit, Romana T. Netea-Maier, Mieke M.J.F. Koenders, Ramnik J. Xavier, Jos W.M. van der Meer, Charles A. Dinarello, Norman Pavelka, Cisca Wijmenga, Richard A. Notebaart, Leo A.B. Joosten, Mihai G. Netea |
| Abstract |
Differences in susceptibility to immune-mediated diseases are determined by variability in immune responses. In three studies within the Human Functional Genomics Project, we assessed the effect of environmental and non-genetic host factors of the genetic make-up of the host and of the intestinal microbiome on the cytokine responses in humans. We analyzed the association of these factors with circulating mediators and with six cytokines after stimulation with 19 bacterial, fungal, viral, and non-microbial metabolic stimuli in 534 healthy subjects. In this first study, we show a strong impact of non-genetic host factors (e.g., age and gender) on cytokine production and circulating mediators. Additionally, annual seasonality is found to be an important environmental factor influencing cytokine production. Alpha-1-antitrypsin concentrations partially mediate the seasonality of cytokine responses, whereas the effect of vitamin D levels is limited. The complete dataset has been made publicly available as a comprehensive resource for future studies. PAPERCLIP. |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 23% |
| Canada | 2 | 9% |
| Chile | 1 | 5% |
| France | 1 | 5% |
| Netherlands | 1 | 5% |
| Malaysia | 1 | 5% |
| Spain | 1 | 5% |
| United Kingdom | 1 | 5% |
| Unknown | 9 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 55% |
| Scientists | 7 | 32% |
| Practitioners (doctors, other healthcare professionals) | 3 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 604 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| Germany | 2 | <1% |
| Spain | 2 | <1% |
| Argentina | 1 | <1% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 592 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 120 | 20% |
| Researcher | 104 | 17% |
| Student > Master | 71 | 12% |
| Student > Bachelor | 58 | 10% |
| Student > Doctoral Student | 31 | 5% |
| Other | 99 | 16% |
| Unknown | 121 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 110 | 18% |
| Biochemistry, Genetics and Molecular Biology | 103 | 17% |
| Immunology and Microbiology | 78 | 13% |
| Medicine and Dentistry | 78 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 2% |
| Other | 64 | 11% |
| Unknown | 158 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 58. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2023.
All research outputs
#751,369
of 26,017,215 outputs
Outputs from Cell
#3,239
of 17,318 outputs
Outputs of similar age
#14,183
of 322,280 outputs
Outputs of similar age from Cell
#65
of 165 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,318 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.7. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,280 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 165 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.