| Title |
Chronobiology, sleep-related risk factors and light therapy in perinatal depression: the “Life-ON” project
|
|---|---|
| Published in |
BMC Psychiatry, November 2016
|
| DOI | 10.1186/s12888-016-1086-0 |
| Pubmed ID | |
| Authors |
Simone Baiardi, Fabio Cirignotta, Alessandro Cicolin, Corrado Garbazza, Armando D’Agostino, Orsola Gambini, Alessandra Giordano, Mariapaola Canevini, Elena Zambrelli, Anna Maria Marconi, Susanna Mondini, Stefan Borgwardt, Christian Cajochen, Nicola Rizzo, Mauro Manconi |
| Abstract |
Perinatal depression (PND) has an overall estimated prevalence of roughly 12 %. Untreated PND has significant negative consequences not only on the health of the mothers, but also on the physical, emotional and cognitive development of their children. No certain risk factors are known to predict PND and no completely safe drug treatments are available during pregnancy and breastfeeding. Sleep and depression are strongly related to each other because of a solid reciprocal causal relationship. Bright light therapy (BLT) is a well-tested and safe treatment, effective in both depression and circadian/sleep disorders. In a 3-year longitudinal, observational, multicentre study, about 500 women will be recruited and followed-up from early pregnancy (10-15 gestational week) until 12 months after delivery. The primary aim of the present study is to systematically explore and characterize risk factors for PND by prospective sleep assessment (using wrist actigraphy, polysomnography and various sleep questionnaires) and bloodbased analysis of potential markers during the perinatal period (Life-ON study). Secondary aims are to explore the relationship between specific genetic polymorphisms and PND (substudy Life-ON1), to investigate the effectiveness of BLT in treating PND (substudy Life-ON2) and to test whether a short term trial of BLT during pregnancy can prevent PND (substudy Life-ON3). The characterization of specific predictive and risk factors for PND may substantially contribute to improve preventive medical and social strategies for the affected women. The study results are expected to promote a better understanding of the relationship between sleep disorders and the development of PND and to confirm, in a large sample of women, the safety and efficacy of BLT both in prevention and treatment of PND. ClinicalTrials.gov NCT02664467 . Registered 13 January 2016. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 210 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | <1% |
| Unknown | 209 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 28 | 13% |
| Student > Master | 26 | 12% |
| Student > Ph. D. Student | 16 | 8% |
| Researcher | 14 | 7% |
| Student > Doctoral Student | 13 | 6% |
| Other | 38 | 18% |
| Unknown | 75 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 35 | 17% |
| Medicine and Dentistry | 32 | 15% |
| Nursing and Health Professions | 19 | 9% |
| Neuroscience | 9 | 4% |
| Agricultural and Biological Sciences | 6 | 3% |
| Other | 22 | 10% |
| Unknown | 87 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2016.
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#13,486,526
of 22,899,952 outputs
Outputs from BMC Psychiatry
#2,841
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Outputs of similar age
#163,398
of 311,298 outputs
Outputs of similar age from BMC Psychiatry
#60
of 97 outputs
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