| Title |
Relationship Between Obesity, Alzheimer’s Disease, and Parkinson’s Disease: an Astrocentric View
|
|---|---|
| Published in |
Molecular Neurobiology, October 2016
|
| DOI | 10.1007/s12035-016-0193-8 |
| Pubmed ID | |
| Authors |
Cynthia Alexandra Martin-Jiménez, Diana Milena Gaitán-Vaca, Valentina Echeverria, Janneth González, George E. Barreto |
| Abstract |
Obesity is considered one of the greatest risk to human health and is associated with several factors including genetic components, diet, and physical inactivity. Recently, the relationship between obesity and numerous progressive and aging-related neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD) have been observed. Thus, the involvement of the most abundant and heterogeneous group of glial cells in neurodegenerative diseases, the astrocytes, is caused by a combination of the failure on their normal homeostatic functions and the increase of toxic metabolites upon pathological event. Upon brain damage, molecular signals induce astrocyte activation and migration to the site of injury, entering in a highly active state, with the aim to contribute to ameliorating or worsening the pathology. In this regard, the aim of this review is to elucidate the relationship between obesity, Alzheimer's disease, and Parkinson's disease and highlight the role of astrocytes in these pathologies. |
Mendeley readers
The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Czechia | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 145 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 17% |
| Student > Master | 19 | 13% |
| Student > Bachelor | 18 | 12% |
| Researcher | 13 | 9% |
| Other | 8 | 5% |
| Other | 20 | 14% |
| Unknown | 44 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 30 | 20% |
| Biochemistry, Genetics and Molecular Biology | 17 | 12% |
| Medicine and Dentistry | 15 | 10% |
| Agricultural and Biological Sciences | 7 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
| Other | 18 | 12% |
| Unknown | 53 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2024.
All research outputs
#2,954,420
of 22,899,952 outputs
Outputs from Molecular Neurobiology
#473
of 3,468 outputs
Outputs of similar age
#52,681
of 313,743 outputs
Outputs of similar age from Molecular Neurobiology
#21
of 114 outputs
Altmetric has tracked 22,899,952 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,468 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,743 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 114 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.