| Title |
Neuroinflammation and psychiatric illness
|
|---|---|
| Published in |
Journal of Neuroinflammation, April 2013
|
| DOI | 10.1186/1742-2094-10-43 |
| Pubmed ID | |
| Authors |
Souhel Najjar, Daniel M Pearlman, Kenneth Alper, Amanda Najjar, Orrin Devinsky |
| Abstract |
Multiple lines of evidence support the pathogenic role of neuroinflammation in psychiatric illness. While systemic autoimmune diseases are well-documented causes of neuropsychiatric disorders, synaptic autoimmune encephalitides with psychotic symptoms often go under-recognized. Parallel to the link between psychiatric symptoms and autoimmunity in autoimmune diseases, neuroimmunological abnormalities occur in classical psychiatric disorders (for example, major depressive, bipolar, schizophrenia, and obsessive-compulsive disorders). Investigations into the pathophysiology of these conditions traditionally stressed dysregulation of the glutamatergic and monoaminergic systems, but the mechanisms causing these neurotransmitter abnormalities remained elusive. We review the link between autoimmunity and neuropsychiatric disorders, and the human and experimental evidence supporting the pathogenic role of neuroinflammation in selected classical psychiatric disorders. Understanding how psychosocial, genetic, immunological and neurotransmitter systems interact can reveal pathogenic clues and help target new preventive and symptomatic therapies. |
X Demographics
The data shown below were collected from the profiles of 60 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 15 | 25% |
| United Kingdom | 6 | 10% |
| Canada | 3 | 5% |
| Japan | 2 | 3% |
| Mexico | 2 | 3% |
| Denmark | 1 | 2% |
| Pakistan | 1 | 2% |
| Switzerland | 1 | 2% |
| Argentina | 1 | 2% |
| Other | 2 | 3% |
| Unknown | 26 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 49 | 82% |
| Practitioners (doctors, other healthcare professionals) | 7 | 12% |
| Scientists | 2 | 3% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
| Unknown | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 788 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | <1% |
| Brazil | 3 | <1% |
| Netherlands | 2 | <1% |
| Ireland | 2 | <1% |
| United Kingdom | 2 | <1% |
| Australia | 1 | <1% |
| France | 1 | <1% |
| Canada | 1 | <1% |
| Mexico | 1 | <1% |
| Other | 6 | <1% |
| Unknown | 763 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 114 | 14% |
| Student > Bachelor | 109 | 14% |
| Student > Ph. D. Student | 99 | 13% |
| Student > Master | 99 | 13% |
| Student > Doctoral Student | 50 | 6% |
| Other | 145 | 18% |
| Unknown | 172 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 190 | 24% |
| Neuroscience | 125 | 16% |
| Agricultural and Biological Sciences | 99 | 13% |
| Biochemistry, Genetics and Molecular Biology | 45 | 6% |
| Psychology | 43 | 5% |
| Other | 78 | 10% |
| Unknown | 208 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 115. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2023.
All research outputs
#370,766
of 25,744,802 outputs
Outputs from Journal of Neuroinflammation
#27
of 2,973 outputs
Outputs of similar age
#2,449
of 213,910 outputs
Outputs of similar age from Journal of Neuroinflammation
#1
of 36 outputs
Altmetric has tracked 25,744,802 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,973 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.