Title |
Chikungunya Virus Infection
|
---|---|
Published in |
Current Infectious Disease Reports, April 2011
|
DOI | 10.1007/s11908-011-0180-1 |
Pubmed ID | |
Authors |
Fabrice Simon, Emilie Javelle, Manuela Oliver, Isabelle Leparc-Goffart, Catherine Marimoutou |
Abstract |
Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes, mostly Aedes aegypti and Aedes albopictus. After half a century of focal outbreaks of acute febrile polyarthralgia in Africa and Asia, the disease unexpectedly spread in the past decade with large outbreaks in Africa and around the Indian Ocean and rare autochthonous transmission in temperate areas. This emergence brought new insights on its pathogenesis, notably the role of the A226V mutation that improved CHIKV fitness in Ae. albopictus and the possible CHIKV persistence in deep tissue sanctuaries for months after infection. Massive outbreaks also revealed new aspects of the acute stage: the high number of symptomatic cases, unexpected complications, mother-to-child transmission, and low lethality in debilitated patients. The follow-up of patients in epidemic areas has identified frequent, long-lasting, rheumatic disorders, including rare inflammatory joint destruction, and common chronic mood changes associated with quality-of-life impairment. Thus, the globalization of CHIKV exposes countries with Aedes mosquitoes both to brutal outbreaks of acute incapacitating episodes and endemic long-lasting disorders. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Jamaica | 3 | 38% |
Congo | 1 | 13% |
Sweden | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | <1% |
Brazil | 2 | <1% |
United Kingdom | 2 | <1% |
Germany | 1 | <1% |
India | 1 | <1% |
Australia | 1 | <1% |
Portugal | 1 | <1% |
Philippines | 1 | <1% |
Unknown | 298 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 52 | 17% |
Student > Master | 43 | 14% |
Researcher | 42 | 14% |
Student > Ph. D. Student | 36 | 12% |
Student > Doctoral Student | 22 | 7% |
Other | 52 | 17% |
Unknown | 63 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 62 | 20% |
Medicine and Dentistry | 57 | 18% |
Immunology and Microbiology | 34 | 11% |
Biochemistry, Genetics and Molecular Biology | 32 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 16 | 5% |
Other | 34 | 11% |
Unknown | 75 | 24% |