| Title |
The pattern of thyroid function of subclinical hypothyroid women with levothyroxine treatment during pregnancy
|
|---|---|
| Published in |
Endocrine, March 2013
|
| DOI | 10.1007/s12020-013-9913-2 |
| Pubmed ID | |
| Authors |
Xiaohui Yu, Yanyan Chen, Zhongyan Shan, Weiping Teng, Chenyang Li, Weiwei Zhou, Bo Gao, Tao Shang, Jiaren Zhou, Bin Ding, Ying Ma, Ying Wu, Qun Liu, Hui Xu, Wei Liu, Jia Li, Weiwei Wang, Yuanbin Li, Chenling Fan, Hong Wang, Hongmei Zhang, Rui Guo |
| Abstract |
In this study, we researched the pattern of thyroid function of subclinical hypothyroid (SCH) women with levothyroxine (LT4) throughout pregnancy and determined the optimal dosages of LT4 for such women. 56 SCH pregnant women were followed regularly prospectively. They were divided into three groups: group A (n = 29. Baseline TSH between 2.5 and 5.0 mIU/L) received 50 μg/day of LT4; group B (n = 17. Baseline TSH between 5.0 and 8.0 mIU/L) received 75 μg/day of L-T4; group C (n = 10. Baseline TSH >8.0 mIU/L) received 100 μg/day of LT4. All the patients started LT4 therapy around the 8th gestational week. Serum TSH, free T4, and free T3 were measured at 4-week intervals throughout pregnancy. Among the thyroid function indexes, serum TSH changed quickly and decreased significantly 4 weeks after LT4 therapy. The change of serum FT4 responded drastically at the 12th gestational week. We also found that serum FT3 did not change much after LT4 therapy. 50, 75, and 100 μg/day can maintain serum TSH level of 79.3, 82.4, and 90.0 % of SCH women in definitive therapeutic goal in group A, B, and C, respectively. The LT4 dose need to be adjusted one or more times in 20.7, 17.6, and 10.0 % of the SCH women in group A, B, and C, respectively. The different LT4 dose can be chosen according to the baseline TSH levels of SCH women. The constant LT4 dose can maintain serum TSH levels of 79.3-90 % patients in the ideal range. A small part of patients require adjust therapy also during the second and third trimester. Therefore, careful follow-up of SCH pregnant women should be taken, and thyroid function should be tested every month until the end of pregnancy. |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 1 | 3% |
| Unknown | 32 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 18% |
| Student > Master | 5 | 15% |
| Student > Doctoral Student | 3 | 9% |
| Student > Bachelor | 3 | 9% |
| Professor > Associate Professor | 3 | 9% |
| Other | 4 | 12% |
| Unknown | 9 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 52% |
| Agricultural and Biological Sciences | 2 | 6% |
| Psychology | 2 | 6% |
| Nursing and Health Professions | 1 | 3% |
| Engineering | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 10 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2013.
All research outputs
#20,187,333
of 22,703,044 outputs
Outputs from Endocrine
#1,354
of 1,676 outputs
Outputs of similar age
#172,667
of 197,434 outputs
Outputs of similar age from Endocrine
#15
of 20 outputs
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