| Title |
Phagocytic Function of Human Blood Polymorphonuclear Leukocytes in the Presence of Carrageenan, a Potential Vaginal Microbicide
|
|---|---|
| Published in |
Inflammation, June 2007
|
| DOI | 10.1007/s10753-007-9029-z |
| Pubmed ID | |
| Authors |
Stephen E. Malawista, Anne de Boisfleury Chevance |
| Abstract |
Carrageenan is currently undergoing clinical trials as the active constituent of a vaginal gel product for use as a female-controlled option to prevent the transmission of HIV during sexual intercourse. Here we show that in the presence of 0.5 mg/ml of carrageenan, human blood polymorphonuclear leukocytes (PMN) do not ingest this material, as evidenced by a lack of progressive vacuolization, but can ingest microorganisms present in the medium, excluding adjacent carrageenan. Moreover, PMN move at normal speeds, respond chemotactically, and reduce nitroblue tetrazolium (NBT) to formazan on stimulation. Hence, in the presence of carrageenan the phagocytic response appears to remain intact. |
Mendeley readers
The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 17% |
| Unknown | 5 | 83% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 33% |
| Lecturer | 1 | 17% |
| Other | 1 | 17% |
| Student > Master | 1 | 17% |
| Professor > Associate Professor | 1 | 17% |
| Other | 0 | 0% |
| Readers by discipline | Count | As % |
|---|---|---|
| Environmental Science | 1 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 17% |
| Biochemistry, Genetics and Molecular Biology | 1 | 17% |
| Mathematics | 1 | 17% |
| Nursing and Health Professions | 1 | 17% |
| Other | 1 | 17% |