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Mendeley readers
Attention Score in Context
| Title |
Binding to F-actin guides cadherin cluster assembly, stability, and movement
|
|---|---|
| Published in |
Journal of Cell Biology, April 2013
|
| DOI | 10.1083/jcb.201211054 |
| Pubmed ID | |
| Authors |
Soonjin Hong, Regina B. Troyanovsky, Sergey M. Troyanovsky |
| Abstract |
The cadherin extracellular region produces intercellular adhesion clusters through trans- and cis-intercadherin bonds, and the intracellular region connects these clusters to the cytoskeleton. To elucidate the interdependence of these binding events, cadherin adhesion was reconstructed from the minimal number of structural elements. F-actin-uncoupled adhesive clusters displayed high instability and random motion. Their assembly required a cadherin cis-binding interface. Coupling these clusters with F-actin through an α-catenin actin-binding domain (αABD) dramatically extended cluster lifetime and conferred direction to cluster motility. In addition, αABD partially lifted the requirement for the cis-interface for cluster assembly. Even more dramatic enhancement of cadherin clustering was observed if αABD was joined with cadherin through a flexible linker or if it was replaced with an actin-binding domain of utrophin. These data present direct evidence that binding to F-actin stabilizes cadherin clusters and cooperates with the cis-interface in cadherin clustering. Such cooperation apparently synchronizes extracellular and intracellular binding events in the process of adherens junction assembly. |
Mendeley readers
The data shown below were compiled from readership statistics for 161 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| Japan | 2 | 1% |
| France | 1 | <1% |
| Netherlands | 1 | <1% |
| Singapore | 1 | <1% |
| Unknown | 152 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 59 | 37% |
| Researcher | 30 | 19% |
| Student > Master | 13 | 8% |
| Student > Bachelor | 11 | 7% |
| Professor > Associate Professor | 9 | 6% |
| Other | 26 | 16% |
| Unknown | 13 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 65 | 40% |
| Biochemistry, Genetics and Molecular Biology | 45 | 28% |
| Physics and Astronomy | 12 | 7% |
| Engineering | 6 | 4% |
| Chemical Engineering | 4 | 2% |
| Other | 11 | 7% |
| Unknown | 18 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2013.
All research outputs
#5,379,297
of 25,374,917 outputs
Outputs from Journal of Cell Biology
#3,676
of 11,939 outputs
Outputs of similar age
#44,263
of 212,995 outputs
Outputs of similar age from Journal of Cell Biology
#18
of 81 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,939 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,995 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.