Title |
Allergens and molecular diagnostics of shellfish allergy
|
---|---|
Published in |
Allergo Journal International, November 2016
|
DOI | 10.1007/s40629-016-0124-2 |
Pubmed ID | |
Authors |
Andreas L. Lopata, Jörg Kleine-Tebbe, Sandip D. Kamath |
Abstract |
Shellfish belongs to "The Big 8" food groups causing allergy, which often does not outgrow during childhood. Shellfish is one of the main food allergens in adults and constitutes a diverse group of species subdivided into crustaceans and mollusks, which seem to include similar but also different allergens. Several pan-allergens are characterized in detail, including tropomyosin and arginine kinase, responsible for clinical cross-reactivity with other invertebrate allergen sources, embracing mites, insects, and parasites. Currently, at least seven different shellfish allergens have been identified, mostly from crustaceans. However, only three recombinant allergens are available for IgE-based routine diagnostic, including tropomyosin, arginine kinase, and sarcoplasmic Ca(2+)-binding protein. Other allergens include myosin light chain, troponin C, triosephosphate isomerase, and actin. This review summarizes the current advances on the molecular characterization of shellfish allergens, clinical cross-reactivity, and current diagnostic approaches for the management of this life-threatening disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 5 | 26% |
United States | 2 | 11% |
Australia | 2 | 11% |
Romania | 2 | 11% |
Curaçao | 1 | 5% |
Taiwan | 1 | 5% |
Canada | 1 | 5% |
Unknown | 5 | 26% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 53% |
Scientists | 5 | 26% |
Practitioners (doctors, other healthcare professionals) | 4 | 21% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 9% |
Student > Master | 3 | 9% |
Other | 2 | 6% |
Unspecified | 2 | 6% |
Student > Postgraduate | 2 | 6% |
Other | 4 | 12% |
Unknown | 17 | 52% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Medicine and Dentistry | 3 | 9% |
Unspecified | 2 | 6% |
Immunology and Microbiology | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Other | 3 | 9% |
Unknown | 19 | 58% |