| Title |
Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space
|
|---|---|
| Published in |
Cell and Tissue Research, September 2016
|
| DOI | 10.1007/s00441-016-2488-5 |
| Pubmed ID | |
| Authors |
Phanee Manganas, Lisa MacPherson, Kostas Tokatlidis |
| Abstract |
Mitochondria are organelles that play a central role in cellular metabolism, as they are responsible for processes such as iron/sulfur cluster biogenesis, respiration and apoptosis. Here, we describe briefly the various protein import pathways for sorting of mitochondrial proteins into the different subcompartments, with an emphasis on the targeting to the intermembrane space. The discovery of a dedicated redox-controlled pathway in the intermembrane space that links protein import to oxidative protein folding raises important questions on the redox regulation of this process. We discuss the salient features of redox regulation in the intermembrane space and how such mechanisms may be linked to the more general redox homeostasis balance that is crucial not only for normal cell physiology but also for cellular dysfunction. |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 19% |
| Student > Master | 12 | 19% |
| Student > Bachelor | 9 | 14% |
| Researcher | 5 | 8% |
| Student > Doctoral Student | 3 | 5% |
| Other | 8 | 13% |
| Unknown | 15 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 27 | 42% |
| Agricultural and Biological Sciences | 12 | 19% |
| Nursing and Health Professions | 1 | 2% |
| Computer Science | 1 | 2% |
| Immunology and Microbiology | 1 | 2% |
| Other | 4 | 6% |
| Unknown | 18 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2023.
All research outputs
#7,862,539
of 23,839,820 outputs
Outputs from Cell and Tissue Research
#527
of 2,279 outputs
Outputs of similar age
#119,086
of 335,528 outputs
Outputs of similar age from Cell and Tissue Research
#5
of 27 outputs
Altmetric has tracked 23,839,820 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,279 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,528 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.