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DNA Methyltransferases - Role and Function

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Cover of 'DNA Methyltransferases - Role and Function'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Mechanisms and Biological Roles of DNA Methyltransferases and DNA Methylation: From Past Achievements to Future Challenges.
  3. Altmetric Badge
    Chapter 2 DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position.
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    Chapter 3 Bacterial DNA Methylation and Methylomes.
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    Chapter 4 Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases.
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    Chapter 5 Enzymology of Mammalian DNA Methyltransferases.
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    Chapter 6 Genetic Studies on Mammalian DNA Methyltransferases.
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    Chapter 7 The Role of DNA Methylation in Cancer.
  9. Altmetric Badge
    Chapter 8 DNA Methyltransferases - Role and Function
  10. Altmetric Badge
    Chapter 9 DNA Methyltransferases - Role and Function
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    Chapter 10 N6-Methyladenine: A Conserved and Dynamic DNA Mark.
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    Chapter 11 Pathways of DNA Demethylation.
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    Chapter 12 Structure and Function of TET Enzymes.
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    Chapter 13 Proteins That Read DNA Methylation.
  15. Altmetric Badge
    Chapter 14 DNA Methyltransferases - Role and Function
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    Chapter 15 DNA Methyltransferases - Role and Function
  17. Altmetric Badge
    Chapter 16 DNA Methyltransferase Inhibitors: Development and Applications.
  18. Altmetric Badge
    Chapter 17 DNA Methyltransferases - Role and Function
  19. Altmetric Badge
    Chapter 18 Engineering and Directed Evolution of DNA Methyltransferases.
  20. Altmetric Badge
    Chapter 19 DNA Labeling Using DNA Methyltransferases.
Attention for Chapter 9: DNA Methyltransferases - Role and Function
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Chapter title
DNA Methyltransferases - Role and Function
Chapter number 9
Book title
DNA Methyltransferases - Role and Function
Published in
Advances in experimental medicine and biology, November 2016
DOI 10.1007/978-3-319-43624-1_9
Pubmed ID
Book ISBNs
978-3-31-943622-7, 978-3-31-943624-1
Authors

Wedd, Laura, Maleszka, Ryszard, Laura Wedd, Ryszard Maleszka

Editors

Albert Jeltsch, Renata Z. Jurkowska

Abstract

In contrast to heavily methylated mammalian genomes, invertebrate genomes are only sparsely methylated in a 'mosaic' fashion with the majority of methylated CpG dinucleotides found across gene bodies. Importantly, this gene body methylation is frequently associated with active transcription, and studies in the honeybee have shown that there are strong links between gene body methylation and alternative splicing. Additional work also highlights that obligatory methylated epialleles influence transcriptional changes in a context-specific manner. Here we discuss the current knowledge in this emerging field and highlight both similarities and differences between DNA methylation systems in mammals and invertebrates. Finally, we argue that the relationship between genetic variation, differential DNA methylation, other epigenetic modifications and the transcriptome must be further explored to fully understand the role of DNA methylation in converting genomic sequences into phenotypes.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 20%
Student > Ph. D. Student 5 20%
Student > Bachelor 3 12%
Professor 2 8%
Student > Master 2 8%
Other 3 12%
Unknown 5 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 40%
Biochemistry, Genetics and Molecular Biology 6 24%
Environmental Science 1 4%
Nursing and Health Professions 1 4%
Business, Management and Accounting 1 4%
Other 0 0%
Unknown 6 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2016.
All research outputs
#15,392,529
of 22,899,952 outputs
Outputs from Advances in experimental medicine and biology
#2,507
of 4,953 outputs
Outputs of similar age
#197,354
of 313,008 outputs
Outputs of similar age from Advances in experimental medicine and biology
#47
of 83 outputs
Altmetric has tracked 22,899,952 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,953 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,008 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.