Title |
Gradual transition from mosaic to global DNA methylation patterns during deuterostome evolution
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Published in |
BMC Bioinformatics, October 2010
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DOI | 10.1186/1471-2105-11-s7-s2 |
Pubmed ID | |
Authors |
Kohji Okamura, Kazuaki A Matsumoto, Kenta Nakai |
Abstract |
DNA methylation by the Dnmt family occurs in vertebrates and invertebrates, including ascidians, and is thought to play important roles in gene regulation and genome stability, especially in vertebrates. However, the global methylation patterns of vertebrates and invertebrates are distinctive. Whereas almost all CpG sites are methylated in vertebrates, with the exception of those in CpG islands, the ascidian genome contains approximately equal amounts of methylated and unmethylated regions. Curiously, methylation status can be reliably estimated from the local frequency of CpG dinucleotides in the ascidian genome. Methylated and unmethylated regions tend to have few and many CpG sites, respectively, consistent with our knowledge of the methylation status of CpG islands and other regions in mammals. However, DNA methylation patterns and levels in vertebrates and invertebrates have not been analyzed in the same way. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 1 | 2% |
Brazil | 1 | 2% |
Sweden | 1 | 2% |
United Kingdom | 1 | 2% |
Denmark | 1 | 2% |
Spain | 1 | 2% |
Japan | 1 | 2% |
Unknown | 45 | 87% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 16 | 31% |
Student > Ph. D. Student | 13 | 25% |
Student > Master | 5 | 10% |
Student > Doctoral Student | 4 | 8% |
Professor > Associate Professor | 3 | 6% |
Other | 7 | 13% |
Unknown | 4 | 8% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 32 | 62% |
Biochemistry, Genetics and Molecular Biology | 10 | 19% |
Environmental Science | 2 | 4% |
Computer Science | 1 | 2% |
Social Sciences | 1 | 2% |
Other | 1 | 2% |
Unknown | 5 | 10% |