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X Demographics
Mendeley readers
Attention Score in Context
| Title |
IgD attenuates the IgM-induced anergy response in transitional and mature B cells
|
|---|---|
| Published in |
Nature Communications, November 2016
|
| DOI | 10.1038/ncomms13381 |
| Pubmed ID | |
| Authors |
Zahra Sabouri, Samuel Perotti, Emily Spierings, Peter Humburg, Mehmet Yabas, Hannes Bergmann, Keisuke Horikawa, Carla Roots, Samantha Lambe, Clara Young, T. Dan Andrews, Matthew Field, Anselm Enders, Joanne H. Reed, Christopher C. Goodnow |
| Abstract |
Self-tolerance by clonal anergy of B cells is marked by an increase in IgD and decrease in IgM antigen receptor surface expression, yet the function of IgD on anergic cells is obscure. Here we define the RNA landscape of the in vivo anergy response, comprising 220 induced sequences including a core set of 97. Failure to co-express IgD with IgM decreases overall expression of receptors for self-antigen, but paradoxically increases the core anergy response, exemplified by increased Sdc1 encoding the cell surface marker syndecan-1. IgD expressed on its own is nevertheless competent to induce calcium signalling and the core anergy mRNA response. Syndecan-1 induction correlates with reduction of surface IgM and is exaggerated without surface IgD in many transitional and mature B cells. These results show that IgD attenuates the response to self-antigen in anergic cells and promotes their accumulation. In this way, IgD minimizes tolerance-induced holes in the pre-immune antibody repertoire. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 29% |
| United States | 2 | 29% |
| Unknown | 3 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Netherlands | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 130 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 23% |
| Student > Ph. D. Student | 24 | 18% |
| Student > Bachelor | 21 | 16% |
| Student > Master | 10 | 8% |
| Student > Doctoral Student | 5 | 4% |
| Other | 10 | 8% |
| Unknown | 33 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 33 | 25% |
| Biochemistry, Genetics and Molecular Biology | 24 | 18% |
| Agricultural and Biological Sciences | 24 | 18% |
| Medicine and Dentistry | 12 | 9% |
| Economics, Econometrics and Finance | 1 | <1% |
| Other | 5 | 4% |
| Unknown | 34 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 66. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2018.
All research outputs
#550,250
of 22,899,952 outputs
Outputs from Nature Communications
#9,711
of 47,180 outputs
Outputs of similar age
#11,931
of 312,766 outputs
Outputs of similar age from Nature Communications
#244
of 959 outputs
Altmetric has tracked 22,899,952 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 47,180 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.8. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,766 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 959 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.