| Title |
A longitudinal study of iron status during pregnancy and the risk of gestational diabetes: findings from a prospective, multiracial cohort
|
|---|---|
| Published in |
Diabetologia, November 2016
|
| DOI | 10.1007/s00125-016-4149-3 |
| Pubmed ID | |
| Authors |
Shristi Rawal, Stefanie N. Hinkle, Wei Bao, Yeyi Zhu, Jagteshwar Grewal, Paul S. Albert, Natalie L. Weir, Michael Y. Tsai, Cuilin Zhang |
| Abstract |
The aim of this study was to prospectively and longitudinally investigate maternal iron status during early to mid-pregnancy, and subsequent risk of gestational diabetes mellitus (GDM), using a comprehensive panel of conventional and novel iron biomarkers. A case-control study of 107 women with GDM and 214 controls (matched on age, race/ethnicity and gestational week during blood collection) was conducted within the the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies-Singleton Cohort (2009-2013), a prospective and multiracial pregnancy cohort. Plasma hepcidin, ferritin and soluble transferrin receptor (sTfR) were measured and sTfR:ferritin ratio was derived, twice before GDM diagnosis (gestational weeks 10-14 and 15-26) and at weeks 23-31 and 33-39. GDM diagnosis was ascertained from medical records. Adjusted ORs (aORs) for GDM were estimated using conditional logistic regression analysis, adjusting for demographics, prepregnancy BMI and other major risk factors. Hepcidin concentrations during weeks 15-26 were 16% higher among women with GDM vs controls (median 6.4 vs 5.5 ng/ml; p = 0.02 ), and were positively associated with GDM risk; the aOR (95% CI) for highest vs lowest quartile was 2.61 (1.07, 6.36). Ferritin levels were also positively associated with GDM risk; the aOR (95% CI) for highest vs lowest quartile was 2.43 (1.12, 5.28) at weeks 10-14 and 3.95 (1.38, 11.30) at weeks 15-26. The sTfR:ferritin ratio was inversely related to GDM risk; the aOR (95% CI) for highest vs lowest quartile was 0.33 (0.14, 0.80) at weeks 10-14 and 0.15 (0.05, 0.48) at weeks 15-26. Our findings suggest that elevated iron stores may be involved in the development of GDM from as early as the first trimester. This raises potential concerns for the recommendation of routine iron supplementation among iron-replete pregnant women. |
X Demographics
The data shown below were collected from the profiles of 54 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 8 | 15% |
| United States | 5 | 9% |
| Spain | 5 | 9% |
| Canada | 3 | 6% |
| Australia | 2 | 4% |
| United Arab Emirates | 1 | 2% |
| Venezuela, Bolivarian Republic of | 1 | 2% |
| Ecuador | 1 | 2% |
| Nepal | 1 | 2% |
| Other | 12 | 22% |
| Unknown | 15 | 28% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 36 | 67% |
| Scientists | 9 | 17% |
| Practitioners (doctors, other healthcare professionals) | 6 | 11% |
| Science communicators (journalists, bloggers, editors) | 3 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Unknown | 125 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 13% |
| Student > Bachelor | 17 | 13% |
| Researcher | 15 | 12% |
| Student > Master | 15 | 12% |
| Other | 7 | 6% |
| Other | 23 | 18% |
| Unknown | 32 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 42 | 33% |
| Nursing and Health Professions | 15 | 12% |
| Agricultural and Biological Sciences | 7 | 6% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Other | 12 | 10% |
| Unknown | 41 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 298. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2021.
All research outputs
#118,582
of 25,754,670 outputs
Outputs from Diabetologia
#79
of 5,378 outputs
Outputs of similar age
#2,399
of 319,924 outputs
Outputs of similar age from Diabetologia
#4
of 79 outputs
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