Title |
Comparison between daily supplementation doses of 200 versus 400 IU of vitamin D in infants
|
---|---|
Published in |
European Journal of Pediatrics, April 2013
|
DOI | 10.1007/s00431-013-1997-4 |
Pubmed ID | |
Authors |
Erman Atas, Ferhan Karademır, Atilla Ersen, Cihan Meral, Secil Aydınoz, Selami Suleymanoglu, Mustafa Gultepe, İsmail Gocmen |
Abstract |
The daily supplementation of vitamin D is mandatory for infants. However, there are still conflicting opinions about the exact daily dose. Thus, we aimed to evaluate a daily supplementation dose of 200 IU is sufficient and compared the supplementation doses of 200 and 400 IU per day. One hundred and sixty-nine infants were randomly assigned to two groups (group 1, 200 IU/day; group 2, 400 IU/day) and there were 75 infants in group 1 and 64 were in group 2 with a total number of 139. The median levels of 25-hydroxyvitamin D3 were significantly increased in group 2 at the age of 4 months (group 1, 39.60 mcg/L; group 2, 56.55 mcg/L; p < 0.0001). We clearly demonstrated that at the age of 4 months, none of the infants on the group 2 had a serum level of 25-hydroxyvitamin D3 less than 30 mcg/L. However, 21.3% of the infants in group 1 had a level below 30 mcg/L. Thus, in order to avoid vitamin D deficiency and rickets, we recommend supplementation dose of vitamin D at 400 IU/day as a safe and effective dose. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 56 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 9 | 16% |
Student > Master | 7 | 13% |
Other | 6 | 11% |
Professor | 5 | 9% |
Researcher | 5 | 9% |
Other | 13 | 23% |
Unknown | 11 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 38% |
Nursing and Health Professions | 5 | 9% |
Agricultural and Biological Sciences | 5 | 9% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 4 | 7% |
Unknown | 17 | 30% |