| Title |
Neurotrophin Signaling and Stem Cells—Implications for Neurodegenerative Diseases and Stem Cell Therapy
|
|---|---|
| Published in |
Molecular Neurobiology, November 2016
|
| DOI | 10.1007/s12035-016-0214-7 |
| Pubmed ID | |
| Authors |
Subrata Pramanik, Yanuar Alan Sulistio, Klaus Heese |
| Abstract |
Neurotrophins (NTs) are members of a neuronal growth factor protein family whose action is mediated by the tropomyosin receptor kinase (TRK) receptor family receptors and the p75 NT receptor (p75NTR), a member of the tumor necrosis factor (TNF) receptor family. Although NTs were first discovered in neurons, recent studies have suggested that NTs and their receptors are expressed in various types of stem cells mediating pivotal signaling events in stem cell biology. The concept of stem cell therapy has already attracted much attention as a potential strategy for the treatment of neurodegenerative diseases (NDs). Strikingly, NTs, proNTs, and their receptors are gaining interest as key regulators of stem cells differentiation, survival, self-renewal, plasticity, and migration. In this review, we elaborate the recent progress in understanding of NTs and their action on various stem cells. First, we provide current knowledge of NTs, proNTs, and their receptor isoforms and signaling pathways. Subsequently, we describe recent advances in the understanding of NT activities in various stem cells and their role in NDs, particularly Alzheimer's disease (AD) and Parkinson's disease (PD). Finally, we compile the implications of NTs and stem cells from a clinical perspective and discuss the challenges with regard to transplantation therapy for treatment of AD and PD. |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 105 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 15% |
| Student > Bachelor | 14 | 13% |
| Student > Master | 12 | 11% |
| Student > Doctoral Student | 11 | 10% |
| Student > Ph. D. Student | 8 | 8% |
| Other | 14 | 13% |
| Unknown | 30 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 17 | 16% |
| Medicine and Dentistry | 16 | 15% |
| Biochemistry, Genetics and Molecular Biology | 13 | 12% |
| Agricultural and Biological Sciences | 11 | 10% |
| Psychology | 6 | 6% |
| Other | 9 | 9% |
| Unknown | 33 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2016.
All research outputs
#4,195,101
of 22,899,952 outputs
Outputs from Molecular Neurobiology
#871
of 3,468 outputs
Outputs of similar age
#70,079
of 311,515 outputs
Outputs of similar age from Molecular Neurobiology
#40
of 121 outputs
Altmetric has tracked 22,899,952 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,468 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 69% of its peers.
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We're also able to compare this research output to 121 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.