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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
|
|---|---|
| Published in |
Nature Genetics, January 2010
|
| DOI | 10.1038/ng.513 |
| Pubmed ID | |
| Abstract |
To identify susceptibility loci for ankylosing spondylitis, we undertook a genome-wide association study in 2,053 unrelated ankylosing spondylitis cases among people of European descent and 5,140 ethnically matched controls, with replication in an independent cohort of 898 ankylosing spondylitis cases and 1,518 controls. Cases were genotyped with Illumina HumHap370 genotyping chips. In addition to strong association with the major histocompatibility complex (MHC; P < 10(-800)), we found association with SNPs in two gene deserts at 2p15 (rs10865331; combined P = 1.9 x 10(-19)) and 21q22 (rs2242944; P = 8.3 x 10(-20)), as well as in the genes ANTXR2 (rs4333130; P = 9.3 x 10(-8)) and IL1R2 (rs2310173; P = 4.8 x 10(-7)). We also replicated previously reported associations at IL23R (rs11209026; P = 9.1 x 10(-14)) and ERAP1 (rs27434; P = 5.3 x 10(-12)). This study reports four genetic loci associated with ankylosing spondylitis risk and identifies a major role for the interleukin (IL)-23 and IL-1 cytokine pathways in disease susceptibility. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 277 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 1% |
| United Kingdom | 3 | 1% |
| Germany | 2 | <1% |
| Turkey | 1 | <1% |
| Colombia | 1 | <1% |
| South Africa | 1 | <1% |
| Australia | 1 | <1% |
| Netherlands | 1 | <1% |
| China | 1 | <1% |
| Other | 3 | 1% |
| Unknown | 259 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 67 | 24% |
| Student > Ph. D. Student | 47 | 17% |
| Student > Master | 26 | 9% |
| Student > Bachelor | 22 | 8% |
| Other | 21 | 8% |
| Other | 63 | 23% |
| Unknown | 31 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 86 | 31% |
| Agricultural and Biological Sciences | 80 | 29% |
| Biochemistry, Genetics and Molecular Biology | 32 | 12% |
| Immunology and Microbiology | 17 | 6% |
| Computer Science | 6 | 2% |
| Other | 16 | 6% |
| Unknown | 40 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2018.
All research outputs
#1,419,807
of 22,705,019 outputs
Outputs from Nature Genetics
#2,116
of 7,176 outputs
Outputs of similar age
#6,506
of 164,032 outputs
Outputs of similar age from Nature Genetics
#7
of 46 outputs
Altmetric has tracked 22,705,019 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,176 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.0. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,032 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.