| Title |
Update on Antithrombotic Therapy for Stroke Prevention in Atrial Fibrillation
|
|---|---|
| Published in |
Current Treatment Options in Cardiovascular Medicine, April 2010
|
| DOI | 10.1007/s11936-010-0069-6 |
| Pubmed ID | |
| Authors |
Hermelinda G. Abcede, Bruce Ovbiagele |
| Abstract |
Atrial fibrillation (AF) is the most common cardiac arrhythmia in the elderly, affecting 1 in 20 adults over the age of 70 years. Stroke is a major yet highly preventable complication of AF, and the strokes related to AF often are disabling and fatal. Warfarin is the treatment of choice in high-risk patients with AF, and its superior efficacy over aspirin for preventing stroke in these patients is widely recognized. However, several eligible patients with AF are not being treated with warfarin or are being treated inadequately, largely because of concerns regarding the attendant strict monitoring, drug interactions, and risk of major bleeding. As such, alternative antithrombotic therapies that can rival or exceed the efficacy of warfarin, yet compare favorably with its administration and side effect profile, are being sought. One such strategy, the use of a combination antiplatelet regimen, for stroke prevention in high-risk patients with nonvalvular AF was investigated recently in two clinical trials. This article reviews the role of combination antiplatelet regimens in stroke prevention for patients with AF. Other therapies discussed include oral anticoagulation, single antiplatelet therapies, oral anticoagulation plus antiplatelet treatment, direct thrombin inhibitors, and factor Xa inhibitors. |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Russia | 1 | 1% |
| France | 1 | 1% |
| Unknown | 79 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 19% |
| Researcher | 14 | 17% |
| Other | 7 | 8% |
| Student > Ph. D. Student | 6 | 7% |
| Student > Doctoral Student | 5 | 6% |
| Other | 22 | 27% |
| Unknown | 13 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 49 | 59% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Social Sciences | 2 | 2% |
| Computer Science | 2 | 2% |
| Agricultural and Biological Sciences | 1 | 1% |
| Other | 6 | 7% |
| Unknown | 19 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2010.
All research outputs
#5,414,817
of 22,705,019 outputs
Outputs from Current Treatment Options in Cardiovascular Medicine
#99
of 409 outputs
Outputs of similar age
#26,163
of 94,635 outputs
Outputs of similar age from Current Treatment Options in Cardiovascular Medicine
#2
of 5 outputs
Altmetric has tracked 22,705,019 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 409 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,635 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.