| Title |
Preeclampsia and Extracellular Vesicles
|
|---|---|
| Published in |
Current Hypertension Reports, September 2016
|
| DOI | 10.1007/s11906-016-0678-x |
| Pubmed ID | |
| Authors |
Sarwat I. Gilani, Tracey L. Weissgerber, Vesna D. Garovic, Muthuvel Jayachandran |
| Abstract |
Preeclampsia is a hypertensive pregnancy disorder characterized by development of hypertension and proteinuria after 20 weeks of gestation that remains a leading cause of maternal and neonatal morbidity and mortality. While preeclampsia is believed to result from complex interactions between maternal and placental factors, the proximate pathophysiology of this syndrome remains elusive. Cell-to-cell communication is a critical signaling mechanism for feto-placental development in normal pregnancies. One mechanism of cellular communication relates to activated cell-derived sealed membrane vesicles called extracellular vesicles (EVs). The concentrations and contents of EVs in biological fluids depend upon their cells of origin and the stimuli which trigger their production. Research on EVs in preeclampsia has focused on EVs derived from the maternal vasculature (endothelium, vascular smooth muscle) and blood (erythrocytes, leukocytes, and platelets), as well as placental syncytiotrophoblasts. Changes in the concentrations and contents of these EVs may contribute to the pathophysiology of preeclampsia by accentuating the pro-inflammatory and pro-coagulatory states of pregnancy. This review focuses on possible interactions among placental- and maternal-derived EVs and their contents in the initiation and progression of the pathogenesis of preeclampsia. Understanding the contributions of EVs in the pathogenesis of preeclampsia may facilitate their use as diagnostic and prognostic biomarkers. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hungary | 1 | <1% |
| Unknown | 112 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 15% |
| Researcher | 13 | 12% |
| Student > Bachelor | 13 | 12% |
| Student > Postgraduate | 8 | 7% |
| Student > Doctoral Student | 6 | 5% |
| Other | 18 | 16% |
| Unknown | 38 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 23% |
| Biochemistry, Genetics and Molecular Biology | 23 | 20% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Agricultural and Biological Sciences | 5 | 4% |
| Immunology and Microbiology | 2 | 2% |
| Other | 7 | 6% |
| Unknown | 45 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2016.
All research outputs
#18,811,512
of 23,313,051 outputs
Outputs from Current Hypertension Reports
#562
of 740 outputs
Outputs of similar age
#259,763
of 338,510 outputs
Outputs of similar age from Current Hypertension Reports
#9
of 10 outputs
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