| Title |
Long-range silencing and position effects at telomeres and centromeres: parallels and differences
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, November 2003
|
| DOI | 10.1007/s00018-003-3246-x |
| Pubmed ID | |
| Authors |
S. Perrod, S. M. Gasser |
| Abstract |
Most of the human genome is compacted into heterochromatin, a form that encompasses multiple forms of inactive chromatin structure. Transcriptional silencing mechanisms in budding and fission yeasts have provided genetically tractable models for understanding heritably repressed chromatin. These silent domains are typically found in regions of repetitive DNA, that is, either adjacent to centromeres or telomeres or within the tandemly repeated ribosomal DNA array. Here we address the mechanisms of centromeric, telomeric and locus-specific gene silencing, comparing simple and complex animals with yeast. Some aspects are universally shared, such as histone-tail modifications, while others are unique to either centromeres or telomeres. These may reflect roles for heterochromatin in other chromosomal functions, like kinetochore attachment and DNA ends protection. |
Mendeley readers
The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| United Kingdom | 1 | <1% |
| Netherlands | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 98 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 31% |
| Researcher | 20 | 19% |
| Professor > Associate Professor | 12 | 12% |
| Professor | 10 | 10% |
| Student > Master | 6 | 6% |
| Other | 12 | 12% |
| Unknown | 12 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 59 | 57% |
| Biochemistry, Genetics and Molecular Biology | 29 | 28% |
| Arts and Humanities | 1 | <1% |
| Psychology | 1 | <1% |
| Medicine and Dentistry | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 12 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2010.
All research outputs
#3,883,063
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#779
of 4,151 outputs
Outputs of similar age
#7,552
of 53,779 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#2
of 20 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 53,779 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.