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X Demographics
Mendeley readers
| Title |
Antidiabetic Activities of Triterpenoids Isolated from Bitter Melon Associated with Activation of the AMPK Pathway
|
|---|---|
| Published in |
Cell Chemical Biology, March 2008
|
| DOI | 10.1016/j.chembiol.2008.01.013 |
| Pubmed ID | |
| Authors |
Min-Jia Tan, Ji-Ming Ye, Nigel Turner, Cordula Hohnen-Behrens, Chang-Qiang Ke, Chun-Ping Tang, Tong Chen, Hans-Christoph Weiss, Ernst-Rudolf Gesing, Alex Rowland, David E. James, Yang Ye |
| Abstract |
Four cucurbitane glycosides, momordicosides Q, R, S, and T, and stereochemistry-established karaviloside XI, were isolated from the vegetable bitter melon (Momordica charantia). These compounds and their aglycones exhibited a number of biologic effects beneficial to diabetes and obesity. In both L6 myotubes and 3T3-L1 adipocytes, they stimulated GLUT4 translocation to the cell membrane--an essential step for inducible glucose entry into cells. This was associated with increased activity of AMP-activated protein kinase (AMPK), a key pathway mediating glucose uptake and fatty acid oxidation. Furthermore, momordicoside(s) enhanced fatty acid oxidation and glucose disposal during glucose tolerance tests in both insulin-sensitive and insulin-resistant mice. These findings indicate that cucurbitane triterpenoids, the characteristic constituents of M. charantia, may provide leads as a class of therapeutics for diabetes and obesity. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 254 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Malaysia | 1 | <1% |
| Switzerland | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 248 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 38 | 15% |
| Student > Ph. D. Student | 37 | 15% |
| Student > Bachelor | 34 | 13% |
| Student > Master | 29 | 11% |
| Other | 14 | 6% |
| Other | 55 | 22% |
| Unknown | 47 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 69 | 27% |
| Biochemistry, Genetics and Molecular Biology | 36 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 28 | 11% |
| Medicine and Dentistry | 25 | 10% |
| Chemistry | 17 | 7% |
| Other | 23 | 9% |
| Unknown | 56 | 22% |