| Title |
Environmental exposure and effects on health of children from a tobacco-producing region
|
|---|---|
| Published in |
Environmental Science and Pollution Research, November 2016
|
| DOI | 10.1007/s11356-016-8071-5 |
| Pubmed ID | |
| Authors |
Sabrina N. Nascimento, Gabriela Göethel, Marília Baierle, Anelise Barth, Natália Brucker, Mariele F. Charão, Angela M. Moro, Bruna Gauer, Elisa Sauer, Juliano Durgante, Marcelo D. Arbo, Flavia V. Thiesen, Tatiana D. Saint’ Pierre, Adriana Gioda, Rafael Moresco, Solange Cristina Garcia |
| Abstract |
Children may be environmentally exposed to several hazards. In order to evaluate the health of children living in a tobacco-producing region, different biomarkers of exposure and effect, as well as hematological parameters, were evaluated. Biomarkers of exposure to the following xenobiotics were assessed: pesticides, nicotine, toxic elements, and organic solvents. Oxidative damage markers malondialdehyde (MDA) and protein carbonyls (PCO), vitamin C, microalbuminuria (mALB) levels, and N-acetyl-β-D-glucosaminidase (NAG) activity were also evaluated. Peripheral blood samples and urine were collected from 40 children (6-12 years), at two different crop periods: in the beginning of pesticide applications (period 1) and in the leaf harvest (period 2). The Wilcoxon signed-rank test for paired data was used to evaluate the differences between both periods. Biomarkers of exposure cotinine in urine and blood chromium (Cr) levels were increased in period 1 when compared to period 2. Moreover, a significant reduced plasmatic activity of butyrylcholinesterase (BuChE) was observed in period 2 in relation to period 1. Blood Cr levels were above the recommended by WHO in both evaluations. The biomarkers MDA and PCO as well as the kidney dysfunction biomarker, mALB, presented levels significantly increased in period 1. Additionally, decreased lymphocytes and increased basophils were also observed. Cotinine was positively associated with PCO, and Cr was positively associated with PCO and MDA. The increased Cr levels were associated with decreased lymphocytes and increased basophils. Our findings demonstrate that children environmentally exposed to xenobiotics in rural area may present early kidney dysfunction, hematological alterations, as well as lipid and protein damages, associated with co-exposure to different xenobiotics involved in tobacco cultivation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 51 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 14% |
| Student > Master | 5 | 10% |
| Professor | 5 | 10% |
| Student > Ph. D. Student | 4 | 8% |
| Student > Doctoral Student | 4 | 8% |
| Other | 11 | 22% |
| Unknown | 15 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Environmental Science | 7 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 10% |
| Medicine and Dentistry | 5 | 10% |
| Nursing and Health Professions | 5 | 10% |
| Biochemistry, Genetics and Molecular Biology | 4 | 8% |
| Other | 9 | 18% |
| Unknown | 16 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2016.
All research outputs
#17,283,763
of 25,371,288 outputs
Outputs from Environmental Science and Pollution Research
#4,362
of 10,869 outputs
Outputs of similar age
#204,676
of 315,902 outputs
Outputs of similar age from Environmental Science and Pollution Research
#74
of 147 outputs
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