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Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation

Overview of attention for article published in Cell Host & Microbe (Science Direct), March 2011
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Title
Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation
Published in
Cell Host & Microbe (Science Direct), March 2011
DOI 10.1016/j.chom.2011.02.009
Pubmed ID
Authors

Maud Bernoux, Thomas Ve, Simon Williams, Christopher Warren, Danny Hatters, Eugene Valkov, Xiaoxiao Zhang, Jeffrey G. Ellis, Bostjan Kobe, Peter N. Dodds

Abstract

The Toll/interleukin-1 receptor (TIR) domain occurs in animal and plant immune receptors. In the animal Toll-like receptors, homodimerization of the intracellular TIR domain is required for initiation of signaling cascades leading to innate immunity. By contrast, the role of the TIR domain in cytoplasmic nucleotide-binding/leucine-rich repeat (NB-LRR) plant immune resistance proteins is poorly understood. L6 is a TIR-NB-LRR resistance protein from flax (Linum usitatissimum) that confers resistance to the flax rust phytopathogenic fungus (Melampsora lini). We determine the crystal structure of the L6 TIR domain and show that, although dispensable for pathogenic effector protein recognition, the TIR domain alone is both necessary and sufficient for L6 immune signaling. We demonstrate that the L6 TIR domain self-associates, most likely forming a homodimer. Analysis of the structure combined with site-directed mutagenesis suggests that self-association is a requirement for immune signaling and reveals distinct surface regions involved in self-association, signaling, and autoregulation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 250 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 <1%
Colombia 1 <1%
Turkey 1 <1%
Australia 1 <1%
New Zealand 1 <1%
Japan 1 <1%
United States 1 <1%
Unknown 242 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 67 27%
Researcher 47 19%
Student > Bachelor 23 9%
Student > Master 21 8%
Student > Doctoral Student 16 6%
Other 33 13%
Unknown 43 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 138 55%
Biochemistry, Genetics and Molecular Biology 49 20%
Immunology and Microbiology 2 <1%
Medicine and Dentistry 2 <1%
Chemistry 2 <1%
Other 9 4%
Unknown 48 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2015.
All research outputs
#16,048,009
of 25,374,647 outputs
Outputs from Cell Host & Microbe (Science Direct)
#2,266
of 2,626 outputs
Outputs of similar age
#92,918
of 120,086 outputs
Outputs of similar age from Cell Host & Microbe (Science Direct)
#13
of 21 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,626 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 51.6. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 120,086 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.